多西他赛联合替吉奥新辅助化疗局部晚期胃癌的疗效  

The efficacy of docetaxel combined with TGA in neoadjuvant chemotherapy of locally advanced gastric cancer

作　　者：方庆丰[1] 周正仕[1] 

机构地区：[1]衢州市人民医院肿瘤科,浙江衢州324000

出　　处：《中国临床药理学杂志》2013年第10期792-794,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察多西他赛联合替吉奥新辅助化疗局部晚期胃癌的疗效及安全性。方法 38例局部晚期胃癌第1 d用多西他赛75 mg·m-2;第1～14d替吉奥80 mg·m-2,分2次餐后口服。21 d为1周期,完成3周期后手术。用彩超、CT、手术、病理评价其疗效,评价指标为有效率、中位生存率(OS)、根治手术切除率、病理完全缓解率。结果 38例患者中36例完成3周期化疗,2例2周期后穿孔急诊手术,其中完全缓解(CR)5例,部分缓解(PR)21例,稳定(SD)6例,进展(PD)6例,总有效率68.42%,中位生存率12个月。行根治性切除25例,姑息切除6例,短路术4例,开关术3例。最常见不良反应为骨髓抑制、脱发、胃肠道反应、周围神经毒性。无化疗相关性死亡。结论多西他赛联合替吉奥新辅助化疗局部晚期胃癌具有较好疗效,毒副作用可以耐受。Objective To observe the safety and the efficacy of docetaxel and TGA in neoadjuvant chemotherapy of locally advanced gastric cancer. Methods All patients with advanced gastric cancer were treated with docetaxel 75 mg·m-2 on the 1^st day and TGA 80 mg· m-2 from 1^st day to 14th day（in two divided oral doses）. All patients received operation after 3 cycles of chemotherapy. Using color doppler ultrasound, CT, operation, pathology to evaluate its clinical efficacy. The main evaluation indicators included the efficiency, the median survival rate, radical operation resection rate and pathological complete remission rate. Results In 38 patients, 36 patients completed 3 cycles of chemotherapy, 2 cases of emergency operation after 2 cycles of perforation. The complete remission （CR） in 5 cases, partial remission （PR） in 21 cases, stable （SD） in 6 cases, progress in 6 cases （PD）. The total effective rate was 68.42% , the median survival was 12 months （OS）. Radical resection in 25 cases, palliative resection in 6 cases. Bypass in 4 cases and switching operation in 3 cases. The most common adverse reactions were myelosuppression, alopeeia, gastrointestinal reaction, peripheral neurotoxicity, 2 cases of gastric perforation, no chemotherapy related death. Conclusion The combination of docetaxel and TGA is well tolerated and effective in neoadjuvant chemotherapy of locally advanced gastric cancer.

关 键 词：胃肿瘤 多西他赛 替吉奥 手术切除 

分 类 号：R979.1[医药卫生—药品] R735.2[医药卫生—药学]