伏立康唑致严重肝损害1例  

Serious liver damage caused by voriconazole in one case

作　　者：蔡小军[1] 宋惠珠[1] 赵敏[1] 

机构地区：[1]南京医科大学附属无锡市人民医院药学部,江苏无锡214023

出　　处：《中国临床药理学杂志》2013年第10期795-796,共2页The Chinese Journal of Clinical Pharmacology

摘　　要：1例81岁男性患者,因肺丝状真菌感染,静滴伏立康唑粉针200 mg,Q12h。治疗3 d后,出现肝损害;后改为伏立康唑片口服100 mg,Q12h,序贯抗真菌,并加用异甘草酸镁注射液150 mg、Qd及复合辅酶粉针等降酶保肝治疗。7 d后,因药物引起肝损害进行性加重,停用伏立康唑;但肝损害继续恶化,致多脏器功能衰竭。A 81 years old male patient with pulmonary filamentous fungal infections, treated with voriconazole injection 200 mg, Q12 h, liver damage occurred after 3 days voriconazole injection used. Hence, voriconazole injection was replaced with voriconazole pills, and treated with Magnesum Isoglycyrrhizinate injection, Coenzyme Complex injection for improving liver function. Unfortunately, the patient liver damage worsened seriously companied multiple organs dysfunction after 7 days the drug used.

关 键 词：伏立康唑 药物不良反应 肝损害 

分 类 号：R969.3[医药卫生—药理学] R978.5[医药卫生—药学]