2型糖尿病患者胰高血糖素及生长抑素功能变化分析  

Changes of glucagon and somatostatin in T2DM patients

作　　者：徐琳[1] 肖正华[1] 陈定宇[1] 

机构地区：[1]广州市第一人民医院内分泌科,广东510080

出　　处：《中国临床新医学》2013年第7期628-631,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广州市医药卫生科技资助项目(编号:201102A213092)

摘　　要：目的检测2型糖尿病患者(T2DM组)及健康人(NC组)的胰岛素(INS)、C肽(C-P)、胰高血糖素(GLC)、生长抑素(SS)的水平,探讨2型糖尿病患者胰岛功能受损可能的机制。方法 T2DM组40例和NC组19名均行口服75g葡萄糖耐量试验(OGTT),于0、30、120min采静脉血,分别测定空腹及口服葡萄糖后30、120min血糖及INS、C-P、GLC、SS。结果 (1)与NC组比较,T2DM组INS、C-P明显降低(P<0.01);(2)T2DM组各时间点GLC较NC组显著升高(P<0.01)。(3)T2DM组口服葡萄糖后30min、120min的SS水平均较0min显著升高,30min较NC组低(P<0.05),120min较NC组高(P<0.01)。结论 T2DM患者INS、C-P分泌水平较正常人显著下降;GLC分泌亢进;SS分泌紊乱。Objective To test the level of serum insulin（INS）,C-peptide（C-P）,glucagon（GLC） and somatostatin（SS） in the type 2 diabetes mellitus（T2DM） patients and the control group in order to find out the possible mechanisms of pancreas islet function impairment in T2DM patients.Methods Forty T2DM patients were used as T2DM group and 19 healthy subjects as control group.All subjects fasted for 10 hours,and received 75 g oral glucose tolerance test（OGTT） at 07：00 hrs.Then the level of PG,INS,C-P,GLC and SS were tested at baseline,30 mins and 120 mins after oral glucose.The level of PG,INS,C-P,GLC and SS were compared between 2 groups statistically.Results（1） Compared with the control group,the level of INS and C-P decreased significantly in T2DM group（P ＆lt; 0.05）.（2） The level of GLC at different time point was higher in the T2DM group than that in the control group（P ＆lt; 0.01）.（3） The SS level at 30 and 120 mins after glucose intake in the T2DM groups were significantly higher than that at baseline compared with the control group,the SS level was lower at 30 mins（P ＆lt; 0.05） and higher at 120 mins（P ＆lt; 0.01） in T2DM group.Conclusion Compared with healthy people the level of the INS and C-P decreased and the level of GLC increased in the T2DM patients.The secretion of the SS in T2DM patients is disorderly.

关 键 词：2型糖尿病 胰岛素 胰高血糖素 生长抑素 

分 类 号：R587.1[医药卫生—内分泌]