冠心病患者血浆CXCL16与斑块稳定性的相关性分析  

Correlation between plasma CXCL16 and plaque stability in patients with coronary heart disease

作　　者：程红[1] 尹琼[1] 

机构地区：[1]湖北省天门市第一人民医院心电图室,湖北天门431700

出　　处：《岭南心血管病杂志》2013年第5期556-560,共5页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨血浆CXCL16与冠心病及粥样斑块稳定性的关系。方法检测正常对照组16例、急性冠状动脉(冠脉)综合征组58例、稳定型心绞痛组22例的血浆CXCL16、基质金属蛋白酶(matrix metalloproteinases,MMP)-1、MMP-2、MMP-9及细胞核因子-κB(nuclear factor-κB,NF-κB)浓度,并进行相关性分析。结果与对照组比较,稳定型心绞痛组和急性冠脉综合征组血浆CXCL-l6、MMP-2、MMP-9及NF-κB浓度均显著升高,差异有统计学意义(P<0.05);与稳定型心绞痛组比较,急性冠脉综合征组血浆CXCLl6、MMP-2及MMP-9浓度显著升高,差异有统计学意义(P<0.05)。相关性分析提示CXCL16与高密度脂蛋白呈负相关(r=-0.368,P<0.05),与C反应蛋白(r=0.392,P<0.05)、MMP-2(r=0.416,P<0.05)、MMP-9(r=0.343,P<0.05)及NF-κB(r=0.447,P<0.05)呈显著正相关。结论CXCLl6可能通过NF-κB调节MMPs的水平进而影响粥样硬化斑块稳定性,介导冠状动脉粥样硬化性心脏病(冠心病)的发生及发展。Objectives To explore the correlation of plasma CXCL16 with plaque stability in patients with coronary heart disease.Methods Plasma concentrations of CXCL16,matrix metalloproteinases （MMP）-1,MMP-2,MMP-9 and nuclear factor-κB （NF-κB） in control group （n=16）,acute coronary syndromes （ACS） group （n=58） and stable angina pectoris （SAP） group （n=22） were measured and analyzed.Results Plasma concentrations of CXCL16,MMP-2,MMP-9 and NF-κB were significantly increased in both ACS and SAP groups than those in control group （P〈0.05）.As compared to those in SAP group,plasma concentrations of CXCL16,MMP-2 and MMP-9 were significantly elevated in ACS group （P〈0.05）.Correlation analysis showed that CXCL16 was negatively correlated with high-density lipoprotein （r=-0.368,P〈0.05）,but was positively correlated with C-reactive protein （r=0.392,P〈0.05）,MMP-2 （r=0.416,P〈0.05）,MMP-9 （r=0.343,P〈0.05） and NF-κB （r=0.447,P〈0.05）.Conclusions CXCL16 may regulate the MMPs levels through affecting NF-κB,thereby affecting atherosclerotic plaque stability and mediating the progress of coronary heart disease.

关 键 词：冠状动脉疾病 CXCL16 基质金属蛋白酶 斑块稳定性 

分 类 号：R541.4[医药卫生—心血管疾病]