哮喘急性发作期患者血清白细胞介素水平变化的临床意义  

Significance of changes of serum interleuldn in patients with acute attack of bronchial asthma

作　　者：李氢元[1] 黄秀霞[1] 张海燕[1] 辛萍[1] 

机构地区：[1]首都医科大学附属北京朝阳医院呼吸与危重症医学科,北京100020

出　　处：《中国医药》2013年第11期1556-1557,共2页China Medicine

摘　　要：目的探讨支气管哮喘（BA）急性发作期患者血清白细胞介素13（IL-13）、IL-23、IL-33水平变化的临床意义。方法应用酶联免疫吸附试验方法检测80例哮喘急性发作期患者（BA组）和60例健康体检者（健康对照组）的血清IL水平。结果BA组血清IL-13、IL-23、IL-33含量均明显高于健康对照组[分别为（2．8±1．6）ng/L比（1．6±0．5）ng／L，（15．9±13．6）ng／L比（5．9±2．2）ng／L，（61．4±28．6）ng/L比（5．3±4．9）ng／L]，差异均有统计学意义（均P＜0．01）。结论BA急性发作期患者血清IL-13、IL-23、IL-33水平升高，提示这3种IL在哮喘急性发作中起到促炎作用，可能参与了哮喘的发病。Objective To explore the serum level of interleukin-13/23/33 in patients with acute attack of bronchial asthma. Methods Eighty patients with acute attack of bronchial asthma were as research subjects, and serum IL-13/IL-23/IL-33 level was detected by enzyme-linked immunosorbent assay. 60 normal people were as con- trol group. Results The serum IL-13, IL-23, IL-33 from asthmatic patients in acute attack were higher than those of normal people [ （ 2.8 ± 1.6） ng/L vs （ 1.6 ± 0.5 ） ng/L, （ 15.9 ± 13.6） ng/L vs （ 5.9 ± 2.2 ） ng/L, （ 61.4 ± 28.6）ng/L vs （5.3 ±4.9）ng/L]（P〈0.01）. Conclusion IL-13, IL-23 and IL-33 play roles in pathology with airway allergic inflammation, which may be one of the reasons for bronchial asthma.

关 键 词：支气管哮喘 急性发作期 白细胞介素 酶联免疫吸附试验 

分 类 号：R562.21[医药卫生—呼吸系统]