脑固定区域内核磁共振成像测量海马结构体积的方法及结果分析  

Measurement of hippocampal formation volume in fixed brain area using magnetic resonance imaging and results analysis

作　　者：钟铧[1,2] 王晓彤[1] 程凯亮[3] 韩青[1] 高倩[1] 王颖[1] 郑雨轩[1] 邵浦 周建英[4] 李幼琼[1] 付强[2] 

机构地区：[1]吉林大学白求恩医学院人体解剖学教研室,吉林长春130021 [2]西藏大学医学院人体解剖学教研室,西藏拉萨850000 [3]吉林大学中日联谊医院放射线科,吉林长春130033 [4]吉林大学第一医院二部麻醉科,吉林长春130031

出　　处：《吉林大学学报（医学版）》2013年第5期999-1003,共5页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(31171152);西藏自治区教育厅资助课题(201210694031);中华医学会与中国高等教育学会项目资助课题(2012-KY-32;2012-FF-80);西藏大学青年科研培育基金项目资助课题(ZDPJZK201312)

摘　　要：目的:探讨采用磁共振成像方法对脑固定区域内海马结构(HF)体积进行测量的可行性,为神经退行性疾病研究提供相关数据。方法:选择吉林大学中日联谊医院自愿参加数据采集的68名成年人作为研究对象,男性33名,女性35名。对颅脑进行3D-fSPGR序列扫描,利用Centricity DICOM viewer 3.0软件对双侧第4脑室外侧缘和双侧玻璃体外侧缘之间的区域进行矢状面10等分,在等分后的图像上逐层勾画HF的面积,乘以层厚计算HF体积。通过SPSS 17.0软件分析HF体积与年龄、性别之间的关系,分析左右两侧HF体积之间的差异和HF体积校正前后差异。结果:HF体积与正常成年人年龄之间不存在线性关系(P>0.05),男性和女性间HF体积比较差异无统计学意义(P>0.05);校正前和校正后右侧HF体积均大于左侧(t=2.091,P<0.05;t=2.032,P<0.05),女性校正后左侧和右侧HF体积均大于校正前(左侧t=-2.092,P<0.05;右侧t=-2.100,P<0.05);正常成人HF平均体积右侧为2 649.92～2 903.17 mm3,左侧为2 579.42～2 803.27mm3。结论:选择对第4脑室外侧缘至玻璃体外侧缘之间的区域进行矢状面10等分的HF体积的研究方法可较全面地对HF体积进行磁共振成像测量,并易于使其研究的标准统一化。Objective To discuss the feasibility of magnetic resonance imaging in measurement of hippocampal formation volume in fixed brain area,and to provide relevant data for research on neurodegenerative diseases.Methods 68cases of adult volunteers from China-Japan Union Hospital of Jilin University were selected（33males and 35females）.The brains of subjects were scaned using 3D-fSPGR sequence.10sagittal images were aquired equally in the area between the bilateral lateral margin of the fourth ventricle and corresponding lateral border of vitreous body.After the outlines of the hippocampal formation were drawed,the volumes of hippocampus were calculated by multiplying by the thickness between two slides and then corrected by cranial cavity volume.The correlations including hippocampal formation volume and cavity volume,hippocampal formation volume and ages or gender were studied.The data were analyzed by using SPSS 17.0software.Results No significant differences were found between the volumes of hippocampal formation and ages（P0.05）or genders（P0.05）.Significant differences were found between the right and lefe hippocampal formation（before correction：t=2.091,P0.05;after correction：t=2.032,P0.05）.Significant difference in the volume of hippocampal formation between before and after correction only existed in female group（left：t=-2.092,P0.05;right：t=-2.100,P 0.05）.According to our data,the average volumes of left and right hippocampal formations in adults were（2 649.92-2 903.17）mm3 and（2579.42-2 803.27）mm3,respectively.Conclusion Magnetic resonance imaging measurement of hoppocampal formation by ten equal sagittal planes,from the lateral border the of fourth ventricle and the lateral border of vitreous body,could standardize the measurement of hippocampus.

关 键 词：海马结构 体积 磁共振成像 矢状面 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.8[医药卫生—诊断学]