单胺类神经递质在碘致甲状腺功能减退症发病过程中的含量变化  

CHANGES OF CONTENTS OF MONOAMINE NEUROTRANSMITTERS IN PROGRESS OF IODINE-INDUCED HYPOTHYROIDISM

作　　者：张琪[1] 陈雯[1] 赵越[1] 陈利琴 沈钧 张万起[1] 

机构地区：[1]天津医科大学公共卫生学院营养与食品卫生教研室 [2]卫生化学教研室,天津300070

出　　处：《营养学报》2013年第5期467-470,共4页Acta Nutrimenta Sinica

基　　金：国家自然基金资助项目(No.30972465)

摘　　要：目的比较高水碘地区甲状腺功能减退（甲减）症患者和健康人群外周血部分单胺类神经递质的水平，探讨单胺类神经逆质在碘过量致甲减发病过程中的作用。方法甲减组为高水碘地区的人群调查中检出的18名甲减患者，对照组为在当地选取的与甲减组患者年龄、性别匹配的18名健康人，尿碘检测表明两组均为碘营养过剩人群。采用高效液相一电化学检测法测定甲减组和对照组人群血浆中多巴胺（DA）、5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）的含量。结果DA、5-HT和5-HIAA的检测在1～200ng／ml的浓度内线性关系良好，回归系数分别为O．9977，O．9987和0．9987。甲减组血浆DA、5-HT和5-HIAA的含量高于正常对照组，分别为（4．25±2．28，3．08±0．41）ng／ml、（5．52±1．48Vs．4．04±0．86）ng／ml和（4．62±1．99，3．59±1．16）ng／ml，差异均具有统计学意义（P〈0．05）。甲减组血浆5-HT含量与FT3水平正相关（R=-0．882，P〈0．001），5-HIAA含量与尿碘浓度正相关（r=-0．483，P=-0．042）；对照组血浆5-HT含量与尿碘浓度负相关（，=-0．746，P=-0．008），与血浆FT3水平负相关（R=-0．732，P=-0．010），与血浆FT4水平正相关（r=0．625，P：0．040）。结论高碘暴露可影响机体内单胺类神经递质的代谢，干扰下丘脑一垂体一甲状腺轴的功能，这可能是碘致甲减的发病过程的中间环节。Objective To explore the role of monoamine neurotransmitters in excess iodine induced hypothyroidism through comparing of the levels plasma monoamine neurotransmitters between hypothyroidism patients and healthy people in high water iodine areas. Methods The hypothyroidism patients who were discovered from the thyroid function survey ahead of this study and healthy people in high water iodine areas were matched by ages and genders. The contents of dopamine （DA）, 5-hydroxytryptamine （5-HT） and 5-hydroxy indoleacetic acid （5-H1AA） were measured by a high performance liquid-electrochemical method. Results All of these neurotransmitters had good linearity within the range of 1-200 ng/ml and regression coefficients were 0.9977, 0.9987 and 0.9987 respectively. The contents of plasma DA, 5-HT and 5-HIAA of hypothyroid group were higher than the control group （P〈0.05）. In hypothyroid group, the plasma 5-HT had a positive correlation with plasma FT4 （r=0.882, P〈0.001）, and the plasma 5-HIAA had a positive correlation with the urine iodine concentration （UIC） （r=0.483, P=0.042）. In control group, the content of 5-HT in plasma had a negative correlation with the urine iodine concentration （r=-0.746, P=0.008）, a negative correlation with the plasma FT3 （r=-0.732, P=0.010） and a positive correlation with the plasma FT4 （r=0.625, P=0.040）. Conclusion High iodine exposure affects the metabolism of monoamine neurotransmitters and disturbs the function of hypothalamus- pituitary-thyroid gland axis, which may be one of the intermediate in factors in iodine-induced hypothyroidism.

关 键 词：甲状腺功能减退 多巴胺 5-羟色胺 5-羟吲哚乙酸 

分 类 号：R581.2[医药卫生—内分泌]