千斤拔的抗肿瘤活性成分研究  

Studies on the Antitumor Constituents in Flemingia Philippinensis Merr. et Rolfe

作　　者：王娇[1,2] 范贤[3] 岑颖洲[3] 

机构地区：[1]海南省兽药饲料监察所,海口570203 [2]暨南大学药学院,广州510632 [3]暨南大学化学系,广州510632

出　　处：《天然产物研究与开发》2013年第10期1315-1319,1361,共6页Natural Product Research and Development

基　　金：国家自然科学基金项目(20772047;21310104);广东省自然科学基金项目(32210018)

摘　　要：通过活性追踪分离从千斤拔(Flemingia philippinensis Merr.et Rolfe.)干燥根中分离到9个化合物,通过现代波谱学方法鉴定化学结构分别为Eriosematin(1);Flemichapparin C(2);咖啡酸三十烷酯(3);Flemiphilippinin A(4);大黄素甲醚(5);染料木黄酮(6);Osajin(7);3,5-二羟基肉桂酸二十八酯(8);Lupinalbin A(9),化合物3和8为千斤拔属中首次分离鉴定。体外抗肿瘤活性研究结果表明,黄酮类化合物1、4、6、7和9对MCF-7、Hela、HepG2、B16细胞均具有较强的增殖抑制活性,可能是千斤拔的主要抗肿瘤活性成分。Bioassay-directed fractionation of the Flemingia philippinensis Merr.et Rolfe led to isolation of compounds by modem chromatography.Nine compounds were isolated and identified as Eriosematin（1）,Flemichapparin C （2）,3＇,4＇-Dihydroxy-trans-cinamic acid myricyl ester（3）,Flemiphilippinin A（4）,Physcion（10）,Genistein（6）,Osajin（7）,octacosyl-3,5-dihydroxy-cinnamate （8）,Lupinalbin A （9）.Compounds 3 and 8 were isolated and identificated from the Flemingia genus for the first time.And their anti-tumor activities were evaluated.Results demonstrated that flavonoids compounds 1,4,6,7 and 9 exhibit significant anti-proliferative activity towards some well established cancer cell lines,e.g.MCF-7,Hela,HepG2 and B16,which showed these flavonoids compounds may be the main anti-cancer compounds of Flemingia philippinensis Merr.et Rolfe.

关 键 词：千斤拔 化学成分 抗肿瘤活性 

分 类 号：P917[天文地球—自然地理学]