乙酰肝素酶在人类自然流产中的作用研究  

Function of the HPSE in the spontaneous abortion of human

作　　者：穆雅琴[1] 刘润花[1] 朱壮彦[1] 王艳红[1] 王健[1] 乔桂兰[1] 崔克[1] 赵富玺[1] 

机构地区：[1]山西大同大学医学院免疫研究所,山西大同037009

出　　处：《现代预防医学》2013年第21期3958-3960,共3页Modern Preventive Medicine

基　　金：山西省青年科学基金资助项目(2010021036);国家人口计生委资助项目(C-73);国家自然基金资助项目(81170621/H0425)

摘　　要：目的研究类乙酰肝素酶(heparanase,HPSE)与人类自然流产的关系,进一步探讨HPSE在妊娠过程中所起的作用。方法采用免疫荧光染色法和实时荧光定量PCR检测选取的非意愿性正常妊娠者流产绒毛组织和早期自然流产者流产绒毛中HPSE的表达情况。结果正常妊娠组的HPSE表达率明显高于自然流产组,差异有统计学意义(P﹤0.05)。结论 HPSE参与正常妊娠过程,自然流产的发生可能与HPSE的低表达有关。OBJECTIVE To investigate the relationship of HPSE, and human normal pregnancy and spontaneous abortion. METHODS By using immunofluorescence technique and real-time fuorescent quantitative PCR, we determined the expression of HPSE in the villus of the human of normal pregnancy and spontaneous abortion. RESULTS The expressions of HPSE in the normal group were significantly increased in comparison with that in the spontaneous abortion group （P 〈 0.05）. CONCLUSION The HPSE participates in the procedure of normal pregnancy, and the lower expression of HPSE may lead to the spontaneous abortion.

关 键 词：自然流产 HPSE 免疫荧光 实时荧光定量PCR 

分 类 号：R714.21[医药卫生—妇产科学]