3种临床类型乙型肝炎患者HBeAg、HBV-DNA及ALT的差异分析  

Analysis of the difference of HBeAg,HBV-DNA and alanine aminotransferase among the three clinical groups of HBV infection

作　　者：苏荣[1] 罗娜[1] 杨延斌[2] 蒋开平[3] 张劲丰[1] 邱腾宇[3] 庄健海[1] 黄星华[1] 何娴[1] 

机构地区：[1]佛山市中医院检验科,广东佛山528000 [2]佛山市中医院统计室 [3]佛山市中医院肝科

出　　处：《现代预防医学》2013年第21期4054-4056,共3页Modern Preventive Medicine

基　　金：佛山市医学类科技攻关项目(201208028)

摘　　要：目的分析慢性乙型肝炎、乙型肝炎肝硬化、原发性肝癌3种临床类型乙型肝炎患者乙型肝炎e抗原(HBeAg)、乙肝病毒脱氧核糖核酸(HBV-DNA)及谷丙转氨酶(ALT)的差异。方法将899例乙型肝炎患者按临床诊断分为慢性乙型肝炎、乙型肝炎肝硬化、原发性肝癌3组,分析不同组患者HBeAg、HBV-DNA、谷丙转氨酶(ALT)的差异。结果慢性乙型肝炎组(51.1%)与乙型肝炎肝硬化组(65.2%)、原发性肝癌组(63.8%)HBeAg阴性率比较差异有统计学意义(P﹤0.01)。慢性乙型肝炎组(28.6%)与乙型肝炎肝硬化组(51.3%)、原发性肝癌组(56.1%)HBV-DNA﹥104 IU/ml的比例差异有统计学意义(P﹤0.001)。慢性乙型肝炎组(32.5%)与乙型肝炎肝硬化组(45.5%)、原发性肝癌组(49.3%)ALT异常率比较差异有统计学意义(P﹤0.001),乙型肝炎肝硬化组、原发性肝癌组ALT平均值明显高于慢性乙型肝炎组(P﹤0.001)。结论 HBeAg阴性并且高水平的HBV-DNA和ALT与乙型肝炎感染的病程进展密切相关,可能是乙型肝炎肝硬化、原发性肝癌发生的危险因素。OBJIECTIVE To analyze the difference of HBeAg, HBV-DNA and alanine aminotransferase （ALT） among the three clinical groups of HBV infection including chronic hepatitis B, cirrhosis and primary hepatic cancer. METHODS A total of 899 cases of HBV infection were classified as chronic hepatitis B, cirrhosis and primary hepatic cancer according to the clinical standards. We analyzed the difference of HBeAg, HBV-DNA and ALT. RESULTS To the level of negative HBeAg, the group of chronic hepatitis B （51.1%） was lower than the group of cirrhosis （65.2%） and the group of primary hepatic cancer （63.8%）, respectively （P 〈 0.01 ）. The levels of HBV-DNA was significantly lower in the group of chronic hepatitis B （28.6%） than in group of cirrhosis （51.3%） and the group of primary hepetic cancer （56.1%）, respectively （P 〈 0.01）. There were also significant differences in the percentages of serum ALT （P 〈 0.01） ： the group of chronic hepatitis B was 32.5% while the group of cirrhosis and the group of primary hepetic cancer was 45.5% and 49.3% respectively （P 〈 0.001）. CONCLUSIONS The levels of negative HBeAg, HBV-DNA and serum ALT are associated with the progression of HBV infection closely, and they may be the risk factors of cirrhosis and primary hepatic cancer.

关 键 词：乙型肝炎 乙型肝炎E抗原 乙肝病毒脱氧核糖核酸 谷丙转氨酶 

分 类 号：R512.62[医药卫生—内科学]