HIF-1α与糖尿病研究进展  

Research progress of HIF-1α and diabetes mellitus

作　　者：谢敏[1] 陈枫[2] 陈庄[2] 

机构地区：[1]泸州医学院附属医院病理科,四川泸州646000 [2]泸州医学院附属医院医学实验中心

出　　处：《现代预防医学》2013年第21期4060-4063,共4页Modern Preventive Medicine

基　　金：四川省重点学科重点建设项目(SZD0241);泸州市科技局课题[2009]1号

摘　　要：低氧诱导因子-1α(HIF-1α)是重要的转录因子,能与β亚基结合形成具有转录活性的二聚体复合物,调控众多下游靶基因的表达,参与低氧适应、血管生成、免疫应答、细胞凋亡等多种反应,在包括糖尿病在内的多种疾病中发挥重要作用。糖尿病中HIF-1α表达水平发生改变,且伴随丙酮醛共价化学修饰导致的结构和功能异常,最终导致血管生成和细胞凋亡等信号通路调控紊乱,是糖尿病及其并发症发生与进展过程中重要的分子事件。遗传学研究显示HIF-1α单核苷酸多态性在糖尿病等疾病中亦发挥重要作用,是其调控紊乱的重要分子基础。本文主要阐述HIF-1α分子信号调控及其单核苷酸多态性在糖尿病中的研究。Hypoxia-Inducible Factor-1 alpha （HIF-1α） is an important transcription factor, which dimerizes with the β subunit and activates downstream target genes. HIF-1α regulates various responses involving hypoxic adaptation, angiogenesis, immunity response and apoptosis, and plays an important role in Diabetes Mellitus （DM）. The changed expression of HIF-1α, and the abnormality of structure and function due to covalent modification with methylglyoxal, result in disorder in angiogenesis and apoptosis, which is an important molecular event in the pathogenesis and progression of DM and its complications. Genetic research has shown that the Single Nucleotide Polymorphisms （SNPs） of HIF-1α also contributes to DM, which is a molecular basis of HIF-1α derangement. This review mainly focuses on the signal regulation and SNPs of HIF-1α in DM.

关 键 词：低氧诱导因子1Α 糖尿病 单核苷酸多态性 信号通路 

分 类 号：R587.1[医药卫生—内分泌]