高压微射流法在纳米药物研究中的应用进展  

Progress in application of high pressure microfluidization in preparation of nanomedicines

作　　者：宋爽[1,2] 郭静[2] 陈曦[2] 徐恩宇[1,2] 姜俊峰[1,2] 靳奇峰[1] 李浩莹[2] 

机构地区：[1]辽宁师范大学化学化工学院,大连116029 [2]苏州大学机电学院生物制造研究中心,苏州215021

出　　处：《中国新药杂志》2013年第20期2388-2391,2413,共5页Chinese Journal of New Drugs

基　　金：辽宁省博士启动基金(20111066);江苏省自然科学基金(BK2011295)

摘　　要：利用高压微射流法改性药物已成为热点。高压微射流技术具有安全无污染、处理时间短、操作简单并且适用于工业化生产的优势,能够制备粒径小且粒度分布均匀的药物,从而提高药物药理药效和使用性能。本文将高压微射流法与其他纳米制备方法进行比较,概述了高压微射流装备的结构与工作原理及其在药物研究中的应用,重点介绍了在纳米混悬剂和纳米乳制备中的应用。The high pressure microfluidiation technique has attracted dramatically increasing attentions in the preparation of nanomedicines, as this novel technology proffers the advantages of safety, non-pollution, simple control, and is suitable for large scale industrial production with high efficiency. In this review, we explained the working principle of high pressure microfluidization, highlighted its advantages in manufacturing nanoparticles, and summarized its application in the preparation of nanomedicines especially nanoemulsion and nanosuspension.

关 键 词：高压微射流 结构 纳米混悬剂 纳米乳 

分 类 号：R912[医药卫生—药学]