血必净注射液的循证应用、不良反应及使用注意事项  

Evidence-based application,adverse drug reactions and precaution of Xuebijing injection

作　　者：卢海儒[1] 樊凌沁[1] 

机构地区：[1]青海省人民医院药学部,西宁810007

出　　处：《中国新药杂志》2013年第20期2449-2452,共4页Chinese Journal of New Drugs

摘　　要：目的:了解血必净注射液的循证应用及不良反应,为合理使用提供参考。方法:对中国知网2012年前发表的关于血必净注射液循证评价及不良反应的文献进行综述。结果:对血必净注射液在脓毒症、多器官功能障碍综合征、急性胰腺炎、肺部感染及急性呼吸窘迫综合征、慢性肺心病心力衰竭的应用进行了循证评价;不良反应发生率约为4.00%,以变态反应为主。结论:在常规治疗的基础上加用血必净注射液,能提高对以上疾病的治疗效果,但尚需进行更严谨的临床试验;并要加强对超说明书使用的管理;使用中要重视变态反应的发生。Objective： To review the evidence-based application and adverse drug reactions of Xuebijing injection, thus provide reference for its rational use. Methods： The published articles related with the evidencebased evaluation and adverse drug reactions of Xuebijing injection in CNKI before 2012 were reviewed. Results： The application of Xuebijing injection in sepsis, multiple organ dysfunction syndrome,acute pancreatitis,pulmonary infection, acute respiratory distress syndrome, and chronic pulmonary heart failure were evaluated using evidence- based method. The incidence of adverse drug reactions was approximately 4.00% , primarily allergy. Conclusion： The addition of Xuebijing injection to conventional treatment can improve the therapeutic effect for these diseases, but more rigorous clinical trials are still needed to confirm this observation. The management of off-label use should be strengthened. In the course of clinical use attention should be paid to the occurrence of allergic reactions.

关 键 词：血必净注射液 循证应用 不良反应 使用注意事项 

分 类 号：R286[医药卫生—中药学]