非小细胞肺癌患者术后化疗结合中医辅助治疗的中期疗效观察  

Medium-Term Clinical Observation of Postoperative Adjuvant Chemotherapy Combined with Chinese Medicine Treatment for Lung Cancer

作　　者：李远静[1] 骆学新[1] 孟小鹏[1] 邹斌[1] 陈维[1] 

机构地区：[1]绍兴市第二人民医院,浙江绍兴312000

出　　处：《中华中医药学刊》2013年第11期2564-2566,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:观察非小细胞肺癌(NSCLC)患者术后GP方案(吉西他滨+顺铂)化疗联合康艾注射液和八珍颗粒中医辅助治疗的中期疗效。方法:按随机数字表法将符合标准的114例患者分为观察组和对照组,观察组48例,对照组66例。对照组术后采用GP方案化疗和对症支持治疗,观察组术后采用GP方案联合康艾注射液和八珍颗粒治疗。4个疗程后比较患者的治疗有效率、生活质量、化疗不良反应以及机体免疫功能。结果:观察组1年期生存率91.67%,2年期生存率68.75%,3年期生存率31.25%。对照组1年期生存率77.27%,2年期生存率46.97%,3年期生存率27.27%。两组比较,1年期和2年期生存率差异均有显著性意义(P<0.05),3年期生存率差异无统计学意义(P>0.05)。治疗后T淋巴细胞亚群比较,两组差异有非常显著性意义(P<0.01)。观察组生活质量改善率56.25%,对照组改善率24.24%,两组比较,差异有显著性意义(P<0.05)。两组患者均出现不同程度不良反应,观察组总发生率77.08%,对照组总发生率100%。两组比较,差异有显著性意义(P<0.05)。不良反应以消化道症状、发热和白细胞降低为主。结论:NSCLC患者术后GP方案化疗过程中联合中药康艾注射液和八珍颗粒,可减轻化疗产生的不良反应,增强患者免疫功能,提高生活质量。Objective：To observe the interim efficacy effect of Addle injection and Chinese medicine treatment of Ba- zhen particles on non small cell lung cancer （NSCLC） patients after GP regimen （gemcitabine plus cisplatin） chemother- apy. Methods ： 114 patients met the standard were randomly divided into observation group and control group, 48 cases in observation group, 66 cases in the control group. With GP chemotherapy and supportive treatment after surgery in the control group, treatment with GP regimen combined with Addle injection and Bazhen granules were used for the patients in the observation group. After 4 courses of treatment, efficiency, quality of life, side effects of chemotherapy and immune function were observed. Results： In the observation group, 1 year survival rate was 91.67% , 2 year survival rate was 68.75% , 3 year survival rate was 31.25%. In control group,1 - year survival rate was 77.27% , 2 year survival rate was 46.97% , 3 year survival rate was 27.27%. Comparing the 2 groups, the 1 - and 2 - year survival rate were signifi- cant differences （ P 〈 0.05 ）, 3 year survival rates were not statistically significant （ P 〉 0.05 ）. After treatment, T lym- phocyte subgroup comparison had a significant difference between 2 groups （ P 〈 0.01 ）. The observation group＇ s quality of life improvement rate was 56.25%, control group＇ s improvement rate was 24.24% , and the difference was significant （P 〈 0.05）. The total incidence rate of adverse reactions in the observation group was 77.08% , in control group was 100%. Comparing the 2 groups, the difference was significant （P 〈 0.05）. The main adverse effects were gastrointesti- nal symptoms, fever and white blood cells. Conclusion ： GP regimen of NSCLC of postoperative patients with combined tra- ditional Chinese medicine Addie injection and Bazhen granules can reduce adverse reactions due to chemotherapy, en- hance immune function, and improve the quality of life.

关 键 词：非小细胞肺癌 吉西他滨 顺铂 康艾注射液 八珍颗粒 

分 类 号：R273[医药卫生—中西医结合]