2-氨基-3,5-二溴苯甲醛的合成研究  

Synthesis of 2-Amino-3,5-dibromobenzaldehyde

作　　者：冯丹琪 施珊珊[1] 王梦洁[1] 邱方利[1] 

机构地区：[1]台州学院医药化工系,浙江台州318000

出　　处：《化学工程师》2013年第10期1-3,9,共4页Chemical Engineer

基　　金：国家自然科学基金资助项目(21106090)

摘　　要：本文介绍2-氨基-3,5二溴苯甲醛的合成新方法。它是以邻硝基苯甲醛为起始原料,铁粉为还原剂,在乙酸和乙醇溶剂中还原,得到邻氨基苯甲醛(Ⅰ),然后Ⅰ与NBS进行溴代反应得到目标产物,总收率为84.3%,产物结构经过1H NMR确证。该方法操作简便,安全性高。A new synthetic method was introduced of 2-Amino-3,5-dibromobenzaldehyde. It was synthesized from o-nitrobenzaldehyde, Iron powder for reducing agent, acetic acid and ethanol as solvent, obtained o-amino benzaldehyde（ I ）. And then bromination by NBS. The overall yield of target product was 84.3%. The product was characterized by IH NMR spectrometry. The method is easy to operate and high safety.

关 键 词：邻硝基苯甲醛 合成 2-氨基-3 5二溴苯甲醛 邻氨基苯甲醛 

分 类 号：TQ244.4[化学工程—有机化工]