PTEN信号通路抑制肿瘤血管新生的研究进展  

Research progress of PTEN pathway in anti-angiogenesis of tumors

作　　者：杨宁(综述)[1] 刘进忠(综述)[1] 成志勇(审校)[2] 

机构地区：[1]河北省保定市第一医院普外科,071000 [2]河北省保定市第一医院血液内科,071000

出　　处：《白血病．淋巴瘤》2013年第10期634-636,共3页Journal of Leukemia & Lymphoma

摘　　要：PTEN基因编码的蛋白具有双特异性磷酸酶活性,其作为PI3K/Akt信号通路的负性调节因子,不仅在调节细胞的增殖、凋亡、周期、多药耐药等方面起着重要作用,而且通过下调PI3K-Akt-VEGF-HIF信号通路抑制多种肿瘤的血管新生.文章对近年来PTEN在调节血管新生方面的研究进展进行综述,以阐明PTEN作为抑制肿瘤血管新生靶点的治疗前景.PTEN is a dual protein/lipid phosphatase.As a negative regulator of PI3K/Akt pathway,PTEN not only plays an important role in multiple cellular functions such as cell metabolism,proliferation,cell-cycle progression,but also modulates angiogenesis via down-regulating PI3K-Akt-VEGF-HIF pathway in many tumors.In this review,the recent studies on the roles and mechanisms of PTEN in regulating tumorigenesis and angiogenesis are discussed to explore PTEN as a favorable prospect target in the treatment of angiogenesis.

关 键 词：肿瘤 PTEN 血管新生 血管内皮生长因子 

分 类 号：R335.6[医药卫生—人体生理学]