穴位注射对含顺铂化疗患者化疗相关恶心呕吐影响的临床试验研究  

Acupoint Injection with Addie Injection for Patients of Nausea and Vomiting with Cisplatin Induced by Chemotherapy

作　　者：芦殿荣[1] 芦殿香[2] 魏萌[3] 何生奇[1] 王芳[1] 高音[1] 张帅[1] 杜艳林[1] 冯利[1] 

机构地区：[1]中国中医科学院望京医院,北京100102 [2]青海大学医学院高原医学研究中心,青海西宁810001 [3]北京中医药大学,北京100029

出　　处：《针灸临床杂志》2013年第10期33-38,共6页Journal of Clinical Acupuncture and Moxibustion

基　　金：望京医院院级资助临床研究课题;编号:2011-11

摘　　要：目的:验证中药艾迪穴位注射是否能够减轻化疗相关性恶心呕吐(CINV),减轻化疗后骨髓毒性反应,提高生活质量,改善中医临床证候。方法:采用随机对照临床试验研究原则,将60例含顺铂化疗方案在院患者随机分为两组:试验组30例患者实施中药艾迪穴位注射联合西药中枢止吐剂盐酸格拉司琼,对照组30例患者单纯静点西药中枢止吐剂盐酸格拉司琼,以顺铂化疗d-1,d1,d21为检测时间点,通过对患者止呕药疗效、骨髓毒性反应、生活质量以及中医证候四项关键性指标进行综合分析、科学评价。结果:试验组患者急性CINV的治疗有效率高于对照组(第一次访视试验组有效率为75.87%,对照组有效率为50.00%,P<0.05;第二次访视试验组有效率为79.31%,对照组有效率为61.54%,P>0.05)。两组患者治疗后血红蛋白及血小板含量均比治疗前低(P<0.05),两组之间相比无统计学意义(P>0.05);两组患者生存质量卡氏计分改善程度比较,试验组变化分值小于对照组(P>0.05);两组患者中医证候总计分差值比较,试验组改善分值大于对照组(P<0.05)。结论:中药艾迪穴位注射能够有效缓解含顺铂化疗方案患者化疗后相关恶心呕吐,并且主要是缓解急性恶心呕吐;两组含顺铂方案化疗患者均合并有骨髓抑制,并且骨髓抑制主要体现在血红蛋白及血小板方面;中药艾迪穴位注射具有改善含顺铂化疗方案患者生活质量的趋势,但两组之间无统计学意义;中药艾迪穴位注射能够改善含顺铂化疗方案患者中医证候积分。Objective:To observe whether the Chinese medicine Addie injection could relieve acute CINV with Cisplatin , reduce bone marrow toxicity after chemotherapy ,improve the quality of life , and improve the clinical syndrome of traditional Chinese medicine .Methods:Use randomized controlled trial principle , divide 60 cases of patients of nausea and vomiting with Cisplatin induced by chemotherapy into two groups :30 cases of patients using traditional Chinese medicine Addie acupoint injection combined with granisetron hydrochloride as testing group , while 30 cases of patients with granisetron hydrochloride as control group .Taking cisplatin D-1 , D1 , D21 as the detection time point , observe efficacy of antiemetic drugs ,bone marrow toxicity , quality of life, as well as the TCM Syndromes , to do comprehensive analysis and scientific evaluation .Results:The treatment effi-ciency of Acute CINV of testing group was higher than that of the control group ( For the first time the testing group was 75.87%; the control group was 50.00%, P <0.05;for the second time the testing group was 79.31%,and the control group was 61.54%,P>0.05).Two groups of patients after chemotherapy , hemoglo-bin and platelet levels were lower than those before chemotherapy ( P<0 .05 ) , between the two groups there was no statistical significance (P>0.05).The quality of life of patients in two groups was compared by Karnof-sky scores ,and the testing group was lower than that of control group ( P>0 .05 ) .As was compared by TCM syndrome improvement rate total scores , testing group was higher than that of control group ( P<0 .05 ) .Con-clusion:Addie acupoint injection can effectively alleviate CINV with cisplatin -based chemotherapy ,mainly al-leviate acute CINV .Patients in two groups after chemotherapy suffer from bone marrow suppression , which was mainly in hemoglobin and platelet .Addie acupoint injection has the trend of improving the quality of life of pa-tients with cisplatin-based chemotherapy , which has no statistical significance betwe

关 键 词：穴位注射 急性化疗相关恶心呕吐 顺铂 

分 类 号：R245.93[医药卫生—针灸推拿学]