水溶性[5-邻(乙氧羰基甲氧基苯基)-10,15,20-Tri(4-N-甲基吡啶基)]卟啉铜(Ⅱ)配合物的合成、表征及其和单核苷酸的相互作用  

Synthesis, Characterization and Interaction with Mononucleotide of [5 o(ethoxycarbonyl methoxyphenyl) 10,15,20 Tris(4 N methylpyridiniumyl) Porphyrinato]copper?

作　　者：韩高义[1] 杨频[2] 

机构地区：[1]南京大学化学系 [2]山西大学分子科学研究所,太原030006

出　　处：《无机化学学报》2000年第6期928-932,共5页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金!( No.29871020)

摘　　要：合成并表征了 [5- o-(乙氧羰基甲氧基苯基 )-10,15,20-Tri(4-N-甲基吡啶基 )]卟啉 H_2[（ 5-o- (Emoph)-Tri(4-N- Mepy)]PP(1)及其铜配合物 Cu[（ 5- o- (Emoph)-Tri(4- N- Mepy)]PP(2),用紫外可见光谱滴定法测定了配合物 (2)与单核苷酸的配位平衡常数，研究了它作为主体分子和单核苷酸的相互作用。研究结果表明，各配体结合常数按 K(dGMP) >K(dAMP) >K(dTMP) >K(dCMP)≥ K(dUMP)的顺序依次减小。测定了π-π配合反应的Δ_rG，Δ_rH，Δ_rS，发现该反应是放热，熵减小的过程，该反应体系存在焓熵补偿关系。5 [o (ethoxylcarbonyl methoxyphenyl) 10,15,20,Tris(N 4 methylpyridiniumyl)]Porphyrin(1) and its copper? derivative(2) were synthesized and characterized by means of spectrophotometer technique. The equilibrium constant of theππ coordination reaction were measured between 2 and mononucleotide and tryptophan by using UV Vis titriation method. The results show that the equilibrium constants decrease in the order of K(dGMP) >K(dAMP) >K(dTMP)> K(dCMP)≥ K(dUMP). The thermodynamic parameters of the complexation reaction were also determined, the results show that the coordination reaction is an exothermal and entropy lose process and the phenomena of enthalpy entropy compensation was observed.

关 键 词：单核苷酸 卟啉 铜配合物 合成 表征 

分 类 号：O614.121[理学—无机化学] Q524[理学—化学]