Keggin结构钼锗稀土杂多蓝的合成性质及抗病毒活性研究  

Synthesis, Properties and Antiviral Activity of Keggin Molybdogemnium Heteropoly Blues

作　　者：刘杰[1] 张黔玲[1] 王丽君[2] 王恩波[3] 黄锦汪[1] 计亮年[1] 

机构地区：[1]超速激光光谱国家重点实验室,中山大学化学化工学院广州510275 [2]吉林医学院,吉林132001 [3]东北师范大学化学系,长春130024

出　　处：《高等学校化学学报》2000年第12期1791-1796,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :3 9870 895 )资助 .

摘　　要：采用电解法合成了一系列 Keggin结构钼锗稀土二电子 Ln H3 [Ge Mo12 O4 0 ]· n H2 O和四电子 Ln H5[Ge Mo12 O4 0 ]·n H2 O杂多蓝 ( Ln=La,Ce,Pr,Nd,Sm,Eu,Gd) .通过 IR,UV-Vis,DTA,XPS和 ESR等方法对产物进行了表征 ,确认杂多蓝仍保持 Keggin结构 ,但结构有轻微的畸变 .研究了 Pr( 2 )对小鼠感染FM1的治疗效果 ,并与阳性对照药物病毒唑作了比较 .结果表明 ,Pr( 2 )具有很好的抗病毒活性 ,甚至超过阳性对照药物病毒唑的抗病毒效果 ,比较两种给药途径 ,结果发现 。Rare earth molybodogemanium \%2e, 4e \%heteropoly blues, LnH 3[GeMo Ⅵ 10 Mo Ⅴ 2O 40 ]·8H 2O and LnH 5[GeMo Ⅵ 8Mo Ⅴ 4O 40 ]·8H 2O(Ln=La, Ce, Nd, Sm, Gd), have been prepared and characterized by IR, UV, TG DTA, XPS, ESR. It is found that the structures of the heteropoly blues still retain the Keggin structure with a slight difference compared with their un reduced compounds. The in vivo activity of Pr(2) against influenza virus(FM1) in the mice was investigated. Pr(2) was administrated perorally(p. o.) and intraperitoneally(i. p.) to 14—16 g Kunming mice infected with FM1. The results show that in contrast to the positive ribavirin, the curative effect of Pr(2) proved to be better and i. p. administration was more effective than p. o. administration. [WT5HZ]

关 键 词：稀土元素 合成 抗病毒活性 钼锗杂多蓝配合物 

分 类 号：O614.33[理学—无机化学]