N-磷酰化氨基酸与核糖核苷反应的研究  

Studies on the Reaction Between N-Phosphoryl Amino Acids and Ribonucleosides

作　　者：胡建军[1] 巨勇[1] 赵玉芬[1] 

机构地区：[1]教育部生命有机磷化学重点实验室

出　　处：《高等学校化学学报》2000年第11期1667-1670,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :39870 415 ;2 96 72 0 2 2 )资助

摘　　要：研究了 N-磷酰化氨基酸与核苷在水溶液中的反应 ,反应中能够同时生成小肽和小的寡核苷酸 ;不同的 N -磷酰化氨基酸与不同的核苷之间的反应具有一定的选择性 .The interaction between N phosphoryl amino acids and nucleosides in aqueous medium was studied and the products were analyzed on the basis of HPLC and LC MS MS techniques. The results demonstrated that peptides and oligonucleotides were simultaneously formed. Different selectivities were observed between the reaction of various kinds of N phosphoryl amino acids and different nucleosides. The results gave some clue for the chemical characteristics of the origin of primordial genetic code.

关 键 词：N-磷酰化氨基酸 核苷酸 生命起源 化学反应 

分 类 号：Q517[生物学—生物化学] Q524