金丝桃素的碘-131标记  

Labeling of Hypericin With Iodine-131

作　　者：孟斌[1] 马娅[1] 朱伟[1] Yicheng Ni 张健[3] 孙自平[1] 

机构地区：[1]山东省医学科学院放射医学研究所,山东济南250062 [2]比利时鲁汶大学 [3]江苏省中医药研究院

出　　处：《中国辐射卫生》2013年第5期610-611,613,共3页Chinese Journal of Radiological Health

摘　　要：目的建立金丝桃素的碘-131标记方法。方法以Iodogen为氧化剂,对金丝桃素进行了碘-131的亲电取代标记。结果在中性反应条件下,使用适当量金丝桃素和Iodogen,标记反应可快速而高效地完成,标记率可高达99%。结论该标记流程操作简单,标记率高,标记物稳定。Objective The aim of this study is to establish the method for labeling hypericin with iodine - 131. Methods we used Iodogen as the oxidant and the hypericin were labelled with iodine - 131 by electrophilic substitution. Re-suits In the neutral reaction conditions, using the proper amount of bypericin and Iodogen, the labeling reaction will com- plete quickly and efficiently and the labeling rate could be as high as 99%. Conclusion The labeling process was relatively simple and the labeling rate was high and the labeled compound was stable.

关 键 词：金丝桃素 碘 Iodogen 

分 类 号：R817.92[医药卫生—影像医学与核医学]