抑肝扶脾清热利湿法对广东地区腹泻型肠易激综合征患者血浆胃肠激素含量的影响  

Effect of method of soothing liver and invigorating spleen,clearing away heat and eliminating dampness on gastrointestinal hormone in patients with diarrhea type irritable bowel syndrome in Guangdong district

作　　者：常东 李健[2] 冯春霞[2] 唐纯志[3] 刘子志[3] 樊亚巍 李辉 何方 

机构地区：[1]武警广东边防总队医院消化内科,广东深圳518029 [2]深圳市中医院消化内科,广东深圳518033 [3]广州中医药大学科研处,广东广州510407

出　　处：《中国中西医结合消化杂志》2013年第10期509-512,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：深圳市科技计划项目(No:200602149);深圳市罗湖区软科学研究计划项目(No:2012075)

摘　　要：[目的]观察抑肝扶脾清热利湿法对广东地区腹泻型肠易激综合征(diarrhea type irritable bowel syndrome,IBS-D)患者血浆胃动素(MTL)、血管活性肠肽(VIP)、生长抑素(SS)、胆囊收缩素(CCK)的影响,并探讨其作用机制。[方法]160例IBS-D患者随机分为2组,中药组采用易激灵2号方,煎取200ml,早晚分服;西药组口服马来酸曲美布丁片(商品名:舒丽启能)0.1g/次、枯草杆菌二联活菌肠溶胶囊(商品名:美常安)0.5g/次,3次/d;2组疗程均为4周。另选20例健康体检者为正常对照组。[结果 ]IBS-D患者血浆CCK、MTL水平较正常对照组明显增高(P<0.01);中药组和西药组自身疗后比较,血浆CCK、MTL水平明显降低(P<0.01,P<0.05);中药组治疗后血浆MTL水平较西药组明显降低(P<0.05)。[结论]抑肝扶脾清热利湿法很可能是通过影响患者胃肠激素水平,达到治疗目的。[Objective] To observe the effect of soothing liver and invigorating spleen, clearing away heat and eliminating dampness on MTL,VIP, SS,CCK in patients with diarrhea type irritable bowel syndrome （IBS-D） in Guangdong. [Methods]The total of 160 patients with IBS-D were assigned to 2 groups：Chinese medicine Group was treated with YIJILING-2, decocted 200 ml, twice daily by oral administration;Western medicine Group was treated with Trimebutine Maleate Tablets 0. lg and Mei changan0. 5g, 3 times daily by oral administration. The therapeutic course was 4 weeks for all. [Results ] The plasma CCK, MTL were sig- nificantly higher in IBS-D patients than in the normal group（P〈0.01）. After treatment,the plasma CCK, MTL were significantly lower in IBS-D patients of Chinese medicine group and western medicine group（P 〈0.01, P〈0.05）, but the plasma MTL in Chinese medicine group was significantly lower than in the western medicine group （P〈0. 05）. [Conclusion] Methed of soothing liver and invigorating spleen,clearing away heat and eliminating dampness could perhaps influence the standard of gastrointestinal hormone and tread the IBS-D effectively.

关 键 词：腹泻型肠易激综合征 中医疗法 胃肠激素 作用机制 

分 类 号：R442.2[医药卫生—诊断学]