薄荷化学成分的研究  

Chemical constituents from Mentha haplocalyx

作　　者：徐凌玉[1,2] 李振麟[2] 蔡芷辰[1,2] 钱士辉[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]江苏省中医药研究院中药资源室,江苏南京210028

出　　处：《中草药》2013年第20期2798-2802,共5页Chinese Traditional and Herbal Drugs

基　　金：国家"十二五"支撑计划项目(2011BA104B06)

摘　　要：目的对薄荷Mentha haplocalyx的化学成分进行研究。方法采用多种柱色谱技术进行分离纯化,并通过波谱分析方法鉴定化合物的结构。结果从薄荷乙醇提取物中分离得到了11个化合物,分别鉴定为薄荷木酚素(1)、5-羟基-6,7,8,4′-四甲氧基黄酮(2)、桦木酸(3)、橙皮素-7-O-β-D-葡萄糖苷(4)、龙胆酸-5-O-β-D-(6′-水杨酰基)-葡萄糖苷(5)、蒙花苷(6)、刺槐素(7)、5-羟基-6,7,8,3′,4′-五甲氧基黄酮(8)、5,6,4′-三羟基-7,8-二甲氧基黄酮(9)、田蓟苷(10)、藿香苷(11)。结论化合物1为新的木酚素类化合物,命名为薄荷木酚素;化合物2为新天然产物;化合物4为首次从唇形科中分离得到;化合物3、5为首次从薄荷属中分离得到。Objective To study the chemical constituents from Mentha haplocalyx. Methods Compounds were isolated and purified by various chromatographic techniques, and their structures were identified by spectral analysis. Results Eleven compounds were isolated and identified, including mentha!ignin （1）, 5-hydroxy-6, 7, 8, 4＇-tetramethoxyflavone （2）, betulinic acid （3）, hesperetin 7-O-β-D-glucopyranoside （4）, gentisic acid 5-O-β-D-（6＇-salicylyl）-glucopyranoside （5）, linarin （6）, acatin （7）, 5-hydroxy-6, 7, 8, 3＇, 4＇-pentamethoxyflavone （8）, 5, 6, 4＇-trihydroxy-7, 8-dimethoxyflavone （9）, tilianin （10）, and agastachoside （11）. Conclusion Compound 1 is a new lignan named menthalignan; compound 2 is a new natural product; compound 4 is isolated from the plants in Labiatae for the first time, and compounds 3 and 5 are firstly reported in the plants ofMentha L.

关 键 词：薄荷 薄荷木酚素 5-羟基-6  7  8  4'-四甲氧基黄酮 桦木酸 橙皮素-7-O-β-D-葡萄糖苷 田蓟苷 

分 类 号：R284.1[医药卫生—中药学]