不同湿度环境下中药浸膏粉体吸湿动力学模型拟合优选  

Optimization of moisture obsorption dynamic model fitting for Chinese materia medica extract powder under different humidity conditions

作　　者：朱诗竟 丁青龙 狄留庆[1,3,4] 赵晓莉[1,3,4] 王令充[1] 祖强[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]常州102医院,江苏常州213000 [3]江苏省中药高效给药系统工程技术研究中心,江苏南京210046 [4]南京市中药微丸产业化工程技术研究中心,江苏南京210023

出　　处：《中草药》2013年第20期2833-2840,共8页Chinese Traditional and Herbal Drugs

基　　金：江苏省“六大人才高峰”支持计划;江苏省“青蓝工程”科技创新团队支持计划[苏教师(2008)30号];江苏省优势学科建设工程资助项目(ysxk-2010)

摘　　要：目的筛选可以准确描述中药浸膏粉体吸湿过程的动力学模型,科学量化吸湿过程,为进一步研究通过中药浸膏粉体改变物理性质来控制吸湿性提供理论基础。方法选择5种模型分别对51种代表性中药浸膏粉体在低、中、高3种相对湿度(33%、57%、73.5%)环境下的吸湿速率曲线进行拟合,以拟合度相关系数(R2)、残差平方(RSS)、信息准则(AIC)值为评价指标,初步筛选拟合较优的动力学模型。结果双指数模型和威布尔模型均能较好地反映中药浸膏粉体吸湿的动力学过程,但双指数模型在不同湿度条件下的适用性较威布尔模型好。结论双指数模型能较好地反映中药浸膏粉体的吸湿动力学过程。Objective To optimize the kinetic model that could accurately describe the moisture absorption progress of Chinese materia medica （CMM） extract powder, to quantify the adsorption process scientifically and to provide the theoretical basis for the further study on controlling the hygroscopicity of CMM extract powder by Changing the physical properties. Methods We chosed five models fitting the hygroscopic rate curve of fifty-one kinds of typical CMM extract powder under the low-, mid-, and high-humidity conditions, as evaluation indexes in R2, RSS, and AIC values, to make the initial screening of optimum kinetic model fitting. Results Both the double exponential model and the Weibull distribution model could reflect the moisture absorption kinetics of CMM extract powder, but the double exponential model had a better adaptability than the Weibull distribution model under different humidity conditions. Conclusion The double exponential model is suitable for reflecting the moisture absorption kinetics of CMM extract powder.

关 键 词：中药浸膏粉体 相对湿度 吸湿过程 动力学模型 优选 

分 类 号：R283[医药卫生—中药学]