川木香煨制前后药效成分在大鼠胃、小肠、结肠中吸收差异研究  被引量:8

Comparative study on absorption of effective components from roasting-processed and crude Vladimiriae Radix in stomach,small intestine,and colon of rats

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作  者:高飞[1] 傅超美[1] 胡慧玲[1] 王战国[2] 彭伟[1] 卢君蓉[1] 盛菲亚[1] 毛茜[1] 

机构地区:[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137 [2]四川大学生命科学院,四川成都610041

出  处:《中草药》2013年第20期2872-2877,共6页Chinese Traditional and Herbal Drugs

基  金:国家自然科学基金青年基金资助项目(81001638)

摘  要:目的比较川木香煨制前后主要药效成分木香烃内酯和去氢木香内酯在大鼠胃、小肠、结肠的吸收差异。方法建立大鼠原位胃、小肠、结肠吸收灌注模型,HPLC-UV法测定给药后各灌注液中木香烃内酯、去氢木香内酯和酚红的量,获取川木香煨制前后主要药效成分在胃、小肠、结肠中吸收动力学参数。结果川木香生品中木香烃内酯和去氢木香内酯在大鼠胃和小肠中的每小时吸收百分率较煨制品高(P<0.05),川木香煨制品中木香烃内酯和去氢木香内酯在结肠中的每小时吸收百分率较生品高(P<0.01)。结论川木香煨制品中药效成分在结肠中吸收速度高于生品。Objective To analyze the absorption difference of the principal active components in Vladimiriae Radix, costunolide and dehydrocostuslactone, between the crude Vladimiriae Radix (CVR) and roasting-processed Vladimiriae Radix (RPVR), in stomach, small intestine, and colon in rats. Methods The in situ perfusion models of stomach, small intestine, and colon in rats were established, the contents of costunolide, dehydrocostuslactone, and phenol red were determined using HPLC-UV method, and the parameters of absorption kinetics of the test object in stomach, small intestine, and colon were obtained. Results The absorption percentage per hour of cosRmolide and dehydrocostuslactone in CVR was higher than that in RPVR in stomach and small intestine of rats (P 〈 0.05). However, the absorption percentage per hour of costunolide and dehydrocos in RPVR was higher than that in CVR in colon of rats (P 〈 0.01). Conclusion The absorption rate ofcstunolide and dehydrocostuslactone in CVR is higher than that in PVR sample in colon of rats.

关 键 词:川木香 煨制 胃肠吸收 木香烃内酯 去氢木香内酯 

分 类 号:R283.1[医药卫生—中药学] R969.1[医药卫生—中医学]

 

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