醒脑静不同制剂给大鼠鼻单向灌流后龙脑和麝香酮吸收比较研究  

Comparative study on absorption of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats

作　　者：温然[1] 陆洋[1] 杨冰[1] 李慧云[1] 赵雪姣[1] 杜守颖[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中草药》2013年第20期2894-2897,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81073057);国家自然科学基金青年科学基金资助项目(81102816)

摘　　要：目的比较醒脑静不同制剂给大鼠鼻单向灌流后其有效成分龙脑和麝香酮吸收特征。方法采用大鼠在体鼻单向灌流模型,GC法测定灌流液中龙脑和麝香酮的量,比较醒脑静滴鼻液与醒脑静微乳中龙脑和麝香酮在大鼠鼻腔的吸收。结果醒脑静滴鼻液中龙脑吸收速率常数(Ka)为(1.00±0.02)min 1,醒脑静微乳中龙脑Ka为(0.76±0.03)min 1;醒脑静滴鼻液中麝香酮Ka为(0.76±0.02)min 1,醒脑静微乳中麝香酮Ka为(0.58±0.10)min 1。结论醒脑静滴鼻液中龙脑和麝香酮在鼻腔的吸收均较醒脑静微乳快。Objective To compare the absorption characteristics of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats. Methods The nasal unidirectional perfusion model was used, the contents of Luodian Borneolum and muscone were determined by GC method, and the absorption of Luodian Borneolum and muscone in Xingnaojing Nasal Drop （XN） and Xingnaojing Microemulsion （XM） were compared. Results The absorption rate constants （Ka） of Luodian Borneolum in XN and XM were （1.00 ± 0.02） and （0.76±0.03） min-1, respectively, and the Ka values of muscone in XN and XM were （0.76 ± 0.02） and （0.58 ± 0.10） min-1, respectively. Conclusion The absorption ofLuodian Borneolum and muscone in XN are both faster than that in XM.

关 键 词：醒脑静滴鼻液 醒脑静微乳 龙脑 麝香酮 鼻单向灌流 鼻吸收 

分 类 号：R969.1[医药卫生—药理学]