临床分离假丝酵母菌感染及其耐药性研究  

STUDY ON THE INFECTION AND DRUG RESISTANCE OF ISOLATED CANDIDA FROM CLINIC

作　　者：钟丽娟[1,2] 陶映[1,2] 于美芳[1,2] 王米兰[1,2] 

机构地区：[1]绍兴市人民医院 [2]浙江大学绍兴医院,浙江绍兴312000

出　　处：《中国消毒学杂志》2013年第10期928-929,共2页Chinese Journal of Disinfection

摘　　要：目的了解临床分离假丝酵母菌感染及其耐药情况。方法通过临床标本分离培养和药敏试验,对本医院住院患者真菌感染标本进行分离鉴定,并对假丝酵母菌耐药性进行了研究。结果在2011年度从本医院住院病人中共分离出1 003株致病真菌,其中白假丝酵母菌检出率最高,构成比为58.9%;其次为热带假丝酵母菌,占23.4%。假丝酵母菌检出率较高的标本为痰液和尿液,检出率分别为49.25%和24.63%。热带假丝酵母菌对伏立康唑敏感率仅为0.9%,对氟康唑、5-氟胞嘧啶、伊曲康唑有不同程度的耐药;光滑假丝酵母菌对氟康唑、伊曲康唑的敏感率为79.8%。结论真菌感染主要分布在呼吸道和泌尿道,假丝酵母菌感染种类增多,耐药性增加。Objective To find out the infection and drug resistance of isolated Candida from clinical. Methods Accord- ing to the isolation of the bacterium from clinical specimens and the antimicrobial susceptibility testing, the isolation and i- dentification of the bacterium from inpatients and the drug resistance were conducted. Results A total of 1 003 strains of pathomycetes were isolated from patients of this hospital in year 2011. The first was Candida albicans, which accounted for 58.9% , and the next was Candida tropicalis, which accounted for 23.4 %. Candida mainly came from sputum and urethra, and the detection rates were 49.5 % and 24.63 % respectively. The resistance rate of Candida tropicalis to Voriconazole tablets was only 0.9 % , and those to Fluconazole,5 - fluorocytosinand and itraconazole with different degrees. The resistance rates of Candida glabrata to Fluconazole and itraconazole were 79.8 %. Conclusion The infection of epiphyte mostly is distributed in respiratory tract and urinary tract. The Candida drug resistance is increasing.

关 键 词：假丝酵母菌 感染 抗真菌药 耐药性 

分 类 号：R181.32[医药卫生—流行病学]