一种2,3,5,6-四甲基吡嗪的简便合成方法研究  

Study on Synthesis of 2,3,5,6-Tetramethylpyrazine by An Easy Method

作　　者：赵伟[1] 刘春波[1] 王昆淼[1] 韩敬美 何沛[1] 刘志华[1] 

机构地区：[1]云南烟草科学研究院/云南省烟草化学重点实验室,云南昆明650106

出　　处：《香料香精化妆品》2013年第5期17-18,共2页Flavour Fragrance Cosmetics

基　　金：中国烟草总公司科技重大专项项目(110201001001);云南中烟工业公司科技开发计划(2012JC02)

摘　　要：利用磷酸氢二铵促进梅拉德反应的性质,通过其与3-羟基-2-丁酮反应合成2,3,5,6-四甲基吡嗪,同时比较考察了3-羟基-2-丁酮与不同铵盐的反应。结果表明,3-羟基-2-丁酮与磷酸氢二铵在室温条件下静置24 h,过滤洗涤即得到2,3,5,6-四甲基吡嗪,产率可达到50%以上,且操作简便,适于工业开发。With the acceleration role of diammonium hydrogen phosphate, an easy method for synthesis of 2,3,5,6-tetrameth ylpyrazine from 3 hydroxy 2 butanone was studied, and different ammonium salts were investigated and compared. The results showed that when 3 hydroxy-2-butanone and diammonium hydrogen phosphate were mixed and rested at room temperature for 24 h, then after washing and filtering, 2,3,5,6-tetramethylpyrazine could be obtained with the total yield over 50%.

关 键 词：3-羟基-2-丁酮 磷酸氢二铵 2 3 5 6-四甲基吡嗪 

分 类 号：TQ655[化学工程—精细化工]