普萘洛尔对映体对点燃的作用及机制  

Mechanism and effects of the enantiomer of chrial medicine Propranolol on kindling

作　　者：李晓玲[1] 张庆[1] 华坚[1] 岳旺[2] 张继国[3] 

机构地区：[1]青岛市立医院,山东青岛266011 [2]青岛大学医学院药学系,山东青岛266021 [3]泰山医学院药理学教研室,山东泰安271016

出　　处：《泰山医学院学报》2013年第7期481-483,共3页Journal of Taishan Medical College

摘　　要：目的研究普萘洛尔对映体对点燃的作用及机制。方法建立大鼠杏仁核电刺激点燃和戊四唑(PTZ)化学性点燃模型,并建立耗竭GABA诱发的小鼠氨基脲惊厥模型,观察普萘洛尔对映体对点燃和惊厥的影响。结果左旋体普萘洛尔腹腔注射有抗PTZ点燃作用,降低Ono’s分级和6级发作百分率(P<0.01),在杏仁核点燃模型能降低Racine分级和发作百分率(P<0.01),在氨基脲诱发的惊厥模型,左旋体可抑制惊厥(P<0.01);右旋体普萘洛尔无抗点燃和惊厥作用。结论左旋体普萘洛尔有抗点燃作用,其可能通过阻断β-受体抑制点燃发作。Objective： To study the mechalnism and effects of the enantiomer of chrial medicine Propranolol on kin- dling. Methods ： The pentylenetetrazo （ FIZ ） chemical kindling and amydala electrical kindling models in rats were estab- lished while the mice semicarbazide convulsion models which were induced by depletion of GABA were constituted. The in- fluence of Propranolol enantiormer on the kindling and convulsion were observed. Results： The laevorctatory form of Prop- ranolol had antikindling effect in the PTZ kindling rats and reduced the Ono＇ s stage and the percentage of VI stage seizure （P 〈 0.01 ）. In amygdala kindling model Racine＇ s stage and the percentage of seize were also reduced （ P 〈 0.01 ）. The laevorotatory form could inhibit the convulsion on the model induced by semicarbazide（ P 〈 0.01 ）. The dextrorotary form of Propranolol didn＇ t show antikindling and convulsive actions. Conclusion： The mechanism of Propranolol inhibits the seize of kindling may be by blocking 13 - adrenoceptor.

关 键 词：普萘洛尔 对映体 点燃 癫痫 

分 类 号：R96[医药卫生—药理学]