去势大鼠股骨与腰椎骨密度改变的比较研究  

Comparative study on the femur and lumber BMD change of ovariectomized rats

作　　者：李亚男[1] 刘慧[2] 倪紫砚[3] 袁艺[4] 石校伟[5] 王东胜[6] 刘洪臣[6] 

机构地区：[1]解放军总医院口腔修复科,副主任医师副教授北京100853 [2]解放军总医院妇产科,副主任医师北京100853 [3]解放军总医院口腔科,主治医师北京100853 [4]解放军总医院妇产科实验室,副主任技师北京100853 [5]解放军总医院口腔放射科,主管技师北京100853 [6]解放军总医院口腔医学研究所,副主任技师北京100853

出　　处：《中华老年口腔医学杂志》2013年第3期136-139,共4页Chinese Journal of Geriatric Dentistry

摘　　要：目的:研究大鼠去势后股骨与腰椎骨密度的变化规律与相关性。方法:6月龄未交配SD雌性大鼠41只,随机分为2组即:A假去势手术组(SHAM),n=20只。B去势手术组(OVX),n=21只。对B组进行卵巢切除术。采用双能X线骨密度测量仪分别在卵巢切除术前、术后1.5个月、3个月及4.5个月测量各组大鼠腰椎3-5及左右股骨远中1/2骨密度,并对骨密度值进行相关性研究。结果:A组大鼠股骨与腰椎骨密度值在各时间测量点无显著差异(P>0.05),B组大鼠股骨与腰椎骨密度随术后时间延长而降低,差异显著(P<0.01)。A、B两组大鼠股骨与腰椎骨密度各时间点均显著相关(P<0.01)。结论:卵巢切除术可致大鼠双股骨远中及腰椎骨密度降低,是制备绝经后骨质疏松动物模型的可靠方法,大鼠腰椎与双股骨骨密度改变具有相关性。Objective： To study the change rule of bone mineral density （BMD）among lumber, right and left femur and their correlations in ovariectomized rats. Methods： 6-month old SD rats were ovariectomized or sham operated and were divided into 2 groups A： SHAM, n=20, B： OVX, n=21. Lumbar spine 3-5 and distal 1/2 part BMD of the right and left femur were measured by dual-energy X- ray absorptimetry before OVX, 1.5 months, 3 months, and 4.5 months after OVX, and the BMD value were statistically analyzed. Results： There was no significant change on lumbar, right and left femur BMD of Group A（P〉0.05）. And the lumbar, right and left femur BMD of Group B decreased significantly（P〈0.01）. There were significant relevence among lumbar, right and left femur BMD at all the time site. Conclusions： ovariectomy could reduce lumbar and femur BMD, and it is a favorable method to prepare postmenopausal osteoporostic animal model. The BMD of rats＇lumbar ,right and left femur have significant correlation.

关 键 词：骨密度 去势手术 腰椎 股骨 

分 类 号：R580[医药卫生—内分泌]