双歧杆菌四联活菌预防医院感染的应用研究  

Study on application of Bifidobacteriumtetravaccine in prevention of nosocomial infections

作　　者：陶磊[1] 涂仲良 王萍[2] 杨秀丽[1] 吴素文[1] 

机构地区：[1]黄冈市妇幼保健院儿内科,湖北黄冈438000 [2]黄冈市中心医院,湖北黄冈438000

出　　处：《中华医院感染学杂志》2013年第22期5402-5403,5406,共3页Chinese Journal of Nosocomiology

基　　金：湖北省黄冈市科研基金项目(EK2012D2100300729)

摘　　要：目的探讨双歧杆菌四联活菌预防住院患儿院内获得性胃肠道和呼吸道感染的作用,为预防医院感染提供参考依据。方法将2011年2月-2012年2月湖北黄冈市妇幼保健院0~6岁1484例住院患儿随机分为两组,试验组758例,对照组726例,试验组患儿自入院起每日口服双歧杆菌四联活菌片(思连康)1.0g,对两组院内胃肠道和呼吸道感染的发生情况进行比较。结果试验组发生胃肠道感染的风险显著低于对照组(RR值0.42,NNT:15,P<0.05);在呼吸道感染发生风险上试验组也明显低于对照组(RR值0.37,NNT:29,P<0.05);就次要结局而言,试验组发生呕吐与腹泻的风险低于对照组(呕吐RR值0.47,NNT:21;腹泻RR值0.30,NNT:19,P<0.05);试验组发生>3d的胃肠道感染(RR值0.40,NNT:15)和>3d的呼吸道感染(RR值0.40,NNT:34)的风险也低于对照组(P<0.05);住院时间≥7d是<7d者感染风险的2.47倍;1~12月龄婴儿的感染风险是非该年龄段的1.62倍。结论双歧杆菌四连活菌可有效预防医院内获得性胃肠道和呼吸道感染。OBJECTIVE To investigate the effect of Bifidobacterium tetravaccine on prevention of hospital-acquired gastrointestinal tract and respiratory tract infections so as to provide basis for the prevention of nosocomial infections. METHODS A total of 1484 hospitalized children aged between 0 and six, who received treatment in Huanggang Maternal and Child Health Hospital from Feb 2011 to Feb 2012, were randomly divided into the study group with 758 cases and the control group with 726 cases; the children in the study group were treated with oral administration of 1.0 g of Bifidobacteriurn tetravaccine tablets （combined） by starting from the admission day, then the incidence of the gastrointestinal tract infections and the respiratory tract infections was observed and compared between the two groups. RESULTS The risk of the gastrointestinal infection was significantly lower in the study group than in the control group （RR：0. 42, NNT： 15,P〈0. 05）; the risk of the respiratory tract infections was also significantly lower in the study group than in the control group（RR： 0. 37, NNT.. 29, P〈0.05）. For the secondary outcomes,the risk of vomiting or diarrhea of the study group was lower than that of the control group （vomiting RR：0. 47, NNT：21;diarrhea RR：O. 30, NNT：lg,P^0. 05）; and the risk of the gastrointestinal infections lasting more than 3 days （RR：0.40,NNT.. 15） and the risk of the respiratory infections lasting more than 3 days （RR：0.40, NNT： 34） were lower in the study group than in the control group. The patients with hospitalization duration more than 7 days were 2.47 times at the risk of infections than those with the hospitalization duration less than 7 days; the infants aged between 1 month and 12 months were 1.62 times at the risk of infections than those of＇other age groups. CONCLUSION The Bifidobacterium tetravaccine tablets can effectively prevent the hospital-acquired gastrointestinal tract and respiratory tract infections.

关 键 词：双歧杆菌四联活菌 预防 胃肠道和呼吸道感染 

分 类 号：R378[医药卫生—病原生物学]