乙型肝炎病毒感染与原发性肝癌的相关性临床研究  

Correlation between hepatitis B virus infection and primary hepatic carcinoma

作　　者：黄元亮[1] 

机构地区：[1]商丘市第一人民医院分院传染科,河南商丘476100

出　　处：《中华医院感染学杂志》2013年第22期5407-5409,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析乙型肝炎病毒感染与原发性肝癌的相关性,为制定原发性肝癌的预防措施提供科学依据。方法选择2009年7月-2012年8月在传染科治疗的184例原发性肝癌患者为研究对象,对所有患者进行病毒性肝炎检测,分析乙型肝炎病毒感染与原发性肝癌的相关性。结果 184例原发性肝癌患者中检出152例患者乙型肝炎病毒感染,检出率77.2%,明显高于其他病毒的检出率;乙型肝炎相关性原发性肝癌患者中,78例患者为抗-HBc(+)、抗-HBe(+)、HBsAg(+)模式,占51.3%,明显高于其他疾病的比例;乙型肝炎病毒基因类型中,109例为C型,占71.7%,差异均有统计学意义(P<0.05)。结论原发性肝癌发病与乙型肝炎病毒密切相关,且感染的乙型肝炎病毒主要以C型基因病毒为主。OBJECTIVE To analyze the correlation between hepatitis B virus infection and primary hepatic carcinoma so as to provide scientific bases for the prevention o; primary hepatic cancer. METHODS Totally 184 patients with primary hepatic carcinoma, who were treated in the infection control department from Jul 2009 to Aug 2012, were enrolled in the study, then the hepatitis B was detected for all the subjects, and the correlation between the hepatitis B virus infection and the primary hepatic carcinoma was analyzed. RESULTS Of totally 184 cases of primary hepatic carcinoma, the detection rate of the hepatitis B virus was 77.2 % （152 cases） , significantly higher than that of other viruses; among the cases of hepatitis D-related primary hepatic carcinoma, there were 78 （51.3%） cases with anti-HBc （＋）, the anti-HBe （＋）, and HBsAg （＋） mode, significantly more than the cases of other diseases . Of the various genotypes of hepatitis B virus, there were 109 （71.7%） cases with type C, the difference was statistically significant （P〈0. 05）. CONCLUSION There is close correlation between the hepatitis B virus and the outbreak of primary hepatic carcinoma, and the genotype C hepatitis B virus is dominant among the viruses causing infections.

关 键 词：乙型肝炎病毒 原发性肝癌 相关性 临床分析 

分 类 号：R512.62[医药卫生—内科学]