系统性红斑狼疮患者感染临床特点及危险因素分析  

Clinical characteristics and risk factors for infections in patients with systemic lupus erythematosus

作　　者：孟岩[1] 王彦焱[1] 罗莉[1] 

机构地区：[1]新疆医科大学第一附属医院风湿科,新疆乌鲁木齐830000

出　　处：《中华医院感染学杂志》2013年第22期5426-5427,5430,共3页Chinese Journal of Nosocomiology

基　　金：高等学校博士学科点专项科研基金项目(200802280004)

摘　　要：目的探讨系统性红斑狼疮患者感染的临床特点以及相关危险因素,研究相关干预措施。方法选取2010年3月-2013年2月风湿科系统性红斑狼疮感染患者80例,总结感染的临床特点以及危险因素,调查数据采用SPSS13.0软件进行统计分析。结果 80例感染患者发生102例次感染,感染部位以呼吸道及尿道感染为主,分别发生35、27例次感染,占34.31%和26.47%;病原菌培养出革兰阴性杆菌44株占43.14%,革兰阳性球菌40株占39.22%;性别、体质量与感染无明显相关,高龄、红斑狼疮涉及多脏器、CRP水平异常、血浆白蛋白异常、激素过量使用、联用免疫抑制剂、发热、白细胞低均是发生医院感染的危险因素。结论系统性红斑狼疮感染发生高危部位为呼吸道及尿道,应注意合理用药,特别关注革兰阴性杆菌与革兰阳性球菌的抗感染治疗,对感染高危因素实施积极预防,减少医院感染的发生。OBJECTIVE To explore the clinical characteristics and related risk factors for infections in the patients with systemic lupus erythematosus so as to put forward corresponding intervention measures. METHODS Totally 80 cases of patients with systemic lupus erythematosus infections, who were treated in the rheumatology department from Mar 2010 to Feb 2013, were enrolled in the study, and 100 cases of patients without infections were set as the non infection group, then the clinical characteristics and risk factors for the infections were observed. RESULTS The infections occurred in 102 case-times of the 80 patients, among which there were 35 （34.31 ~ ） case-times of respiratory tract infections and 27 （26.47 ~） case-times of urinary tract infections. Of the pathogens isolated, there were 44 （43. 14~） strains of gram-negative bacilli and 40 （39.22~） strains of gram- positive cocci. There was no significant correlation between the gender, body mass index, and the infections, while the advanced age, erythematosus involving multiple organs, abnormal level of CRP, abnormal plasma albumin, overuse of hormone, combination use of immunosuppressants, fever, and low level of white blood cells were the risk factors for the nosocomial infections. CONCLUSION The systemic lupus erythematosus infections are prone to occur in the respiratory tract and urinary tract; it is necessary to pay attention to the reasonable medication and special attention to the treatment of infections caused by the gram-negative bacilli and the gram-positive cocci and prevent the high risk factors for the infections so as to reduce the incidence of nosocomial infections.

关 键 词：系统性红斑狼疮 医院感染 临床特点 危险因素 

分 类 号：R181.32[医药卫生—流行病学]