La(Ⅲ)配合物的抗氧化性和DNA结合性质研究  

Anti-oxidation and DNA binding properties of La(Ⅲ) complexes

作　　者：刘永春[1] 徐秀英[2] 雷瑞霞[1] 张小伟[1] 武芸[1] 杨正银[3] 

机构地区：[1]陇东学院化学化工学院,甘肃庆阳745000 [2]陇东学院岐伯医学院,甘肃庆阳745000 [3]兰州大学化学化工学院,甘肃兰州730000

出　　处：《化学研究与应用》2013年第11期1475-1483,共9页Chemical Research and Application

基　　金：甘肃省教育厅研究生导师计划项目(1010B-04)资助

摘　　要：由8-羟基喹啉-2-甲醛和四个芳香酰肼合成的四种希夫碱配体分别与La（NO3）3·6H2O反应合成了四个La（Ⅲ）配合物。La（Ⅲ）和每个配体均形成双核的1：1（金属：配体）型9配位配合物。这些配合物均能与小牛胸腺DNA以插入作用较强结合，结合力常数为10^-6～10^7L·mol^-1。这些配合物均有较强的清除羟基自由基和超氧负离子自由基的抗氧化活性。含有酚羟基基团的配合物表现出较强的清除羟基自由基的活性．而含有N-杂环基团的配合物表现出较强的清除超氧负离子自由基的活性。Four La （III） complexes were prepared from La（NO3）3·6H2O and four Schiff-base ligands that were synthesized from 8- hydroxyquinoline-2-carboxyaldehyde and four aroylhydrazines, respectively. La （III） and every ligand formed a binuclear La （III） complex with 1 ： 1 metal-to-ligand stoichiometry and nine-coordination at the La （III） center. All the complexes could bind to Calf thymus DNA through intercalation with the binding constant at the order of 10^-6～10^7L·mol^-1. All the complexes showed strong abilities of anti-oxidation against hydroxyl radicals and superoxide radicals. However, complex containing active phenolic hydroxyl group showed stronger scavenging effects on hydroxyl radicals and complex containing N-heteroaromatic substituent showed stronger scavenging effects on superoxide radicals.

关 键 词：抗氧化 小牛胸腺DNA 稀土金属配合物 希夫碱 DNA插入试剂 

分 类 号：O614.813[理学—无机化学]