间充质干细胞与支气管哮喘  

Mesenchymal stem cells and bronchial asthma

作　　者：李洁[1] 莫碧文[1] 

机构地区：[1]桂林医学院附属医院呼吸内科,桂林541001

出　　处：《国际呼吸杂志》2013年第21期1657-1660,共4页International Journal of Respiration

基　　金：国家自然科学基金（81260009）;国家自然科学基金（30760083）;广西自然科学基金重点课题（2012GXNSFDA053020）;广西卫生厅重点课题（重200976）

摘　　要：间充质干细胞是一种具有多向分化潜能的成体干细胞，拥有强大的免疫调节能力。它可减轻支气管哮喘（简称哮喘）的气道炎症，有利于哮喘的治疗，又可参与哮喘的气道重塑，加重哮喘病理改变，具有双面性。若能深入探讨、明确其在哮喘中的作用机制，趋利避害，可望给哮喘的治疗开辟更广阔的前景。Mesenchymal stem cells are pluripotent adult stem cells, which have powerful immunomodulatory capacity. These ceils have dual character in the treatment of bronchial asthma （asthma）. One is they can reduce airway inflammation and conducive to the treatment of asthma. On the other hand, they can involve in airway remodeling and aggravate the pathological changes of asthma. If they could be done an in-depth inquiry, to clarify their mechanism of action in asthma, and to avoid the disadvantages, the prospects of treatment of asthma will have a extensive future.

关 键 词：间充质干细胞 支气管哮喘 气道炎症 气道重塑 

分 类 号：R562.25[医药卫生—呼吸系统]