瑞格列奈与甘精胰岛素联合治疗新诊断2型糖尿病的疗效观察  

Curative effects of repaglinide and repaglinide combining insulin glargine on newly diagnosed type 2 diabetes

作　　者：姚璐[1] 孙建敏[1] 吕肖峰[1] 

机构地区：[1]北京军区总医院内分泌科,北京100700

出　　处：《中国循证心血管医学杂志》2013年第5期481-482,共2页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的：比较新诊断2型糖尿病患者应用胰岛素促泌剂瑞格列奈单一治疗及联合长效胰岛素甘精胰岛素治疗12周后血糖水平的差异。方法纳入2012年1月~2013年1月北京军区总医院新诊断2型糖尿病患者48例，随机分为单药治疗组（n=24）及联合治疗组（n=24），单药治疗组仅餐前口服瑞格列奈（初始计量0.5 mg），联合治疗组除餐前服用瑞格列奈外，每晚8 pm皮下注射甘精胰岛素（初始计量6 u）。根据血糖水平调整用药剂量，治疗12周后观察两组空腹静脉血糖（FBG）水平、餐后2小时血糖（2 hPBG）水平、糖化血红蛋白（HbA1c）水平及血糖达标时间。结果与单药治疗组相比，联合治疗组FBG[（5.9±1.6）mmol/L vs.（6.8±1.5）mmol/L]、2 hPBG[（8.8±0.9）mmol/L vs.（9.2±0.8）mmol/L]、HBA1c[（7.4±0.5）% vs.（7.8±1.3）%]均更低，且血糖达标时间明显缩短[（6.1±1.3）d vs.（8.9±2.5）d]。结论胰岛素促泌剂与长效胰岛素联合治疗2型糖尿病初始治疗较单独应用胰岛素促泌剂效果更好，并能促使血糖尽快达标。Objective To compare the difference in blood glucose level in the patients with newly diagnosed type 2 diabetes treated with only repaglinide or repaglinide combining insulin glargine for 12 weeks. Methods The patients （n=48） were chosen from the General Hospital of PLA Beijing Military Area Command from Jan. 2012 to Jan. 2013, and randomly divided into repaglinide group and combining group （each n=24）. The repaglinide group was orally given repaglinide （0.5 mg initially） before meals and combining group was given oral repaglinide and hypodermic injection of insulin glargine （6 u initially） at every 8 pm. The dosages of the drugs were adjusted according to patients’ blood glucose level. The levels of fasting blood glucose （FBG）, 2-hour postprandial blood glucose （2-h PBG） and HbA1C, and control time of blood glucose were observed in two groups after treatment for 12 weeks. Results Compared with repaglinide group, the levels of FBG [（5.9±1.6） mmol/L vs. （6.8±1.5） mmol/L], 2-h PBG [（8.8±0.9） mmol/L vs. （9.2±0.8） mmol/L] and HBA1C [（7.4±0.5）%vs. （7.8±1.3）%] were lower, and control time of blood glucose was shorter [（6.1±1.3） d vs. （8.9±2.5） d] in combining group. Conclusion Repaglinide combining insulin glargine has better curative effect on type 2 diabetes than only repaglinide, which can improve blood glucose reaching normal level.

关 键 词：瑞格列奈 甘精胰岛素 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]