冠心病病损分布特点与低血流剪切力的关系  

Correlation between Distribution of Coronary Lesions and Low Shear Stress

作　　者：高文辉[1] 崔翰斌[1] 

机构地区：[1]宁波大学医学院,浙江宁波315000

出　　处：《医学综述》2013年第21期3871-3874,共4页Medical Recapitulate

摘　　要：冠状动脉粥样硬化性心脏病(冠心病)是一种多因素的疾病,除了传统的危险因素(如高血压、糖尿病、血脂异常、吸烟、肥胖等)以外,近年来又发现了一些新的危险因素,如睡眠呼吸暂停低通气综合征、D-型人格、牙周病等。冠状动脉血管树由于心脏的形状而有多数方向改变,亦承受较小的血流剪应力。发生内皮损害的部位在人群中的分布有一定的规律,这正好符合血流动力学特点的部位,这些部位正好是血流切应力低的部位,每一种危险因素都有一定的分布规律,这可以指导粥样斑块的危险评分和预测,针对不同的危险因素进行特殊的干预措施,为冠心病的二级预防提供更完善的二级预防理论。Coronary heart disease is a disease of multiple risk factors. Besides the traditional risk factors such as hypertension, diabetes, abnormal lipids, smoking, obesity, some new risk factors have recently been discovered such as sleep apnea hyp0pnea syndrome, D-type of personality, periodontal disease etc.. Coronary artery vascular tree due to the heart shape resulted most direction changes, also bears a blood flow of shear stress. Therefore, there is a certain rule of endothelial damage position distribution influenced by different risk factors in the crowd, which just accords with the characteristics Of hemodynamic position, which are the posi- tions of low blood shear stress. Each kind of risk factors has certain distribution law, which can guide us the atheromatous plaque risk scoring and the forecast, and give special intervention measures for different risk factors, provide more perfect secondary prevention theory for the secondary prevention of coronary heart disease.

关 键 词：冠心病 危险因素 病损部位 切应力 

分 类 号：R541.4[医药卫生—心血管疾病]