β纤维蛋白原-455G/A基因多态性与冠心病的关系  

Association of β-fibrinogen-455 G/A Polymorphism with Coronary Heart Disease

作　　者：陈琪 

机构地区：[1]宁波市第四医院急诊科,浙江省宁波市315700

出　　处：《中国动脉硬化杂志》2013年第10期931-934,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的分析β纤维蛋白原(血浆纤维蛋白原B)基因启动子区-455 bp位点多态性与冠心病的关系。方法采用聚合酶链反应限制性片长多态性分析法检测240例冠心病患者和240例正常对照者的β纤维蛋白原基因启动子区-455 bp位点多态性,并测定血浆纤维蛋白原水平。结果 (1)冠心病组GA/AA基因型及A等位基因频率(分别为45.4%和25.2%)均高于对照组(分别为26.7%和15.2%),差异有统计学意义(P均<0.05);(2)冠心病组各基因型的血浆纤维蛋白原水平均高于对照组同基因型,两组携带GA基因型者的血浆纤维蛋白原水平高于同组携带GG基因型者,携带AA基因型者血浆纤维蛋白原水平高于同组携带GA基因型者,差异有统计学意义(P均<0.05)。结论β纤维蛋白原基因启动子区-455 bp位点多态性与冠心病有关,A等位基因是冠心病的易感危险因素,可能通过影响血浆纤维蛋白原水平与冠心病产生联系。Aim To explore the association of -455G/A polymorphisms of β-fibrinogen gene with coronary heart disease. Methods 240 coronary heart disease patients and 240 normal people were involved. -455G/A polymorphisms of β-fibrinogen gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-PFLP）,and the plasma fibrinogen was determined. Results （1）The frequency of GA/AA genotype and A-allele （45.4% and 25.2%） was significantly higher in coronary heart disease group compared with their controls（26.7% and 15.2%）（P〈0.05）. （2）The level of fibrinogen of each genotype in coronary heart disease group was significantly higher than the same genotype of the control group In each group,the level of fibrinogen of patients with GA genotype was significantly higher than those of patients with GG genotype,the level of fibrinogen of patients with AA genotype was significantly higher than those of patients with GA genotype（P〈0.05）. Conclusion β-fibrinogen gene -455G/A polymorphism may be related to coronary heart disease,the A-allele may be the risk genetic factor for coronary heart disease,and maybe have contact with coronary heart disease by influencing the level of fibrinogen.

关 键 词：Β纤维蛋白原 基因多态性 冠心病 

分 类 号：R5[医药卫生—内科学]