可溶性细胞间黏附分子1与老年单纯收缩期高血压血管内皮功能相关  

Correlation between soluble intercellular adhesion molecule-1 and vascular endothelial function in elderly patients with isolated systolic hypertension

作　　者：刘忠玉[1] 黄榕[2] 周亚丽[2] 

机构地区：[1]安徽医科大学新疆临床学院 [2]新疆维吾尔自治区人民医院干保二科,新疆乌鲁木齐830001

出　　处：《中华高血压杂志》2013年第10期974-978,共5页Chinese Journal of Hypertension

基　　金：新疆维吾尔自治区自然科学基金资助项目(2011211A053);新疆维吾尔自治区人民医院院内基金(20090108)

摘　　要：目的探讨可溶性细胞间黏附分子1(sICAM-1)与老年单纯收缩期高血压(ISH)血管内皮功能的关系。方法采用横断面研究方法,连续收集2011-07-2012-07入住新疆维吾尔自治区人民医院干保二科的老年ISH患者110例作为ISH组,年龄65～95(74.2±7.3)岁;老年原发性高血压(EH)患者110例作为EH组,年龄65～94(72.3±7.3)岁;并选择年龄与之相匹配的正常血压人群80人作为对照组,年龄65～92(73.3±5.5)岁。采用ELISA法测定血清sICAM-1、晚期糖基化终末产物(AGE)浓度,Griess法测定血清一氧化氮含量;运用超声技术测定血流介导的内皮依赖性血管舒张功能(FMD),动脉硬化检测仪测定颈股动脉脉搏波传导速度(cfPWV)。采用直线相关分析及多元线性逐步回归分析法分析sICAM-1与其他指标的相关性。结果与对照组比较,老年ISH组、EH组sICAM-1[(191.52±37.59)、(137.28±27.70)比(88.84±20.31)μg/L]、AGE[(285.48±46.60)、(176.69±22.42)比(108.76±17.46)μg/L]、cfPWV[(1798.3±58.4)、(1548.8±105.2)比(975.4±101.6)cm/s]水平升高(均P<0.05),一氧化氮[(7.30±1.78)、(8.45±2.75)比(16.04±2.70)μmol/L]、FMD[(11.95±5.07)%、(12.25±3.34)%比(21.40±6.32)%]降低(均P<0.05)。相关分析得出,sICAM-1与AGE、cfPWV呈正相关(分别r=0.728,0.752,均P<0.05);sICAM-1与一氧化氮、FMD呈负相关(分别r=-0.794,-0.669,均P<0.05);多元线性逐步回归分析显示sICAM-1、一氧化氮是影响FMD的主要因素(分别β=-0.438,0.315,均P<0.05)。结论老年ISH患者血清sICAM-1水平明显升高,且与FMD呈负相关。Objective To investigate the relationship between soluble intercellular adhesion molecule-1 （sICAM 1） and vascular endothelial function of elderly patients with isolated systolic hypertension （ISH）. Methods From Ju-ly, 2011 to July, 2012, 220 inpatients were enrolled, including 110 ISH patients age from 65 to 95 [mean age of （ 74.2±7.3） ] and 110 EH patients age from 65 to 94 [mean age of （ 72.3 ± 7.3 ） ]. Meanwhile 80 normotensive participants age from 65 to 92 [age of（ 73.3 ± 5.5）] were served as control. Serum soluble intercellular adhesion molecule-1 （sICAM-1） and advanced glycation end products （AGE） concentration were measured by ELISA. Nitric oxide （NO） was determined by Griess method, the association between sICAM-1 and FMD and cfPWV were described by linear correlation analysis and multiple linear stepwise regression analysis. Results Compared with those of control group, slCAM-1 [（191.52 ± 37.59）, （137.28±27.70） vs （88.8±9 20.31）μg/L], AGE [（285.48±46.60）, （176.69±22.42） vs （108.76±17.46）μg/L], cfPWV [（1798.3±58.4）, （1548.8±105.2） vs （975.4±101.6）cm/s] in ISH and EH groups were higher （all P〈0.05）, while the concentration of NO [（7.30±9 1.78）, （8.45±2.75） vs （16.0±2.70）μmol/L] and FMD [（11.95±5.07）%, （12.25±3.34）% vs （21.40±9 6.32）%] were lower （all P〈0.05）. sICAM-1 positively correlated with AGE and efPWV （r=0. 728, P〈0.05; r=0.752, P〈0.05）, but negatively correlated with NO and FMD （r=-0.794, P〈0.05; r=-0.669, P〈 0.05）. Multiple linear regression analysis showed that sICAM-1 and NO were the important factors of FMD （β=-0. 438, β=0. 315, all P〈0. 05）. Conclusion sICAM-1 significantly elevated in elderly patients with isolated systolic hypertension and negatively correlated with FMD.

关 键 词：单纯收缩期高血压 可溶性细胞间黏附分子1 血流介导的内皮依赖性血管舒张功能 脉搏波传导 速度 

分 类 号：R544.1[医药卫生—心血管疾病]