Adsorbents in blood purification: From lab search to clinical therapy  

作　　者：YU YaoTing 

机构地区：[1]Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University

出　　处：《Chinese Science Bulletin》2013年第35期4357-4361,共5页

基　　金：supported the Nankai research group for so many years

摘　　要：Various types of porous resins adsorbents based on polystyrene,polyvinyl alcohol,cellulose as matrixes and DNA,amino acids with other biological active molecules as ligands were extensively studied at Nankai University.Molecular recognition between the ligand and pathogenic molecule was investigated.Several commercialized products are now widely used in hospitals all over China.Whole blood hemoperfusion are used to treat patients suffering from autoimmune diseases,uremia acute intoxication and hyperbilirubinemia.Clinical performances of hundreds and thousands of patients,treated by whole blood sorption therapy are safe,efficient(90%)and cost-effective.Various types of porous resins adsorbents based on polystyrene, polyvinyl alcohol, cellulose as matrixes and DNA, amino acids with other biological active molecules as ligands were extensively studied at Nankai University. Molecular recognition between the ligand and pathogenic molecule was investigated. Several commercialized products are now widely used in hospitals all over China. Whole blood hemoperfusion are used to treat patients suffering from autoimmune diseases, uremia acute intoxication and hyperbilirubinemia. Clinical performances of hundreds and thousands of patients, treated by whole blood sorption therapy are safe, efficient （90%） and cost-effective.

关 键 词：树脂吸附剂 临床治疗 血液净化 实验室 生物活性分子 自身免疫性疾病 聚苯乙烯 聚乙烯醇 

分 类 号：R459.5[医药卫生—治疗学]