Current status of research and application in vascular stents  

作　　者：QI PengKai YANG Ying MAITZ F Manfred HUANG Nan 

机构地区：[1]Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University [2]School of Materials Science and Engineering, Southwest Jiaotong University [3]Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden 01097, Germany

出　　处：《Chinese Science Bulletin》2013年第35期4362-4370,共9页

基　　金：supported by the National Basic Research Program of China(2011CB606204);the National Natural Science Foundation of China(81330031,81271701)

摘　　要：Cardiovascular diseases have been the leading cause of death in modern society.Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions.During the twenty-five years’development of vascular stents,revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged.In this review,the evolution of vascular stents is summarized,aiming to provide a glimpse into the future of vascular stents.Advanced designs,focusing on the investigations of new substrates,new platforms,new drugs and new biomolecules are currently under evaluation with promising clinical studies.The concept of"time sequence functional stent"has been raised in this paper.It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization.It also shows long-term inertness without release of toxic ions or toxic degradation products.The success of this concept is briefly presented with a clinical study in this model stents.Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years＇ development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of ＂time sequence functional stent＂ has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents.

关 键 词：血管支架 心血管疾病 应用 冠状动脉 内皮祖细胞 干预措施 生物分子 时间序列 

分 类 号：R543[医药卫生—心血管疾病]