犬ECMO期间动静脉二氧化碳分压差与心输出量的关系  

Relationship between Pcv-aCO_2 and cardiac output of dogs during ECMO

作　　者：仇杰[1] 刘宏生[1] 费忠化[1] 张春英[1] 马冬纹[1] 刘新梅[1] 蔡国强[1] 褚衍林[1] 

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《山东医药》2013年第38期18-20,共3页Shandong Medical Journal

基　　金：济宁市科技局资助项目[济科字(2011)57号]

摘　　要：目的研究犬在体外膜肺氧合(ECMO)辅助期间动静脉二氧化碳分压差(Pcv-aCO2)与心输出量(CO)的关系。方法 5只犬经股静脉放置中心静脉管,股动脉放置动脉测压管连接有创心输出量监测仪及心电监护仪,采用股静脉—颈静脉ECMO模式进行辅助,于ECMO建立前(T0)、转机后即可(T1)、辅助1 h(T2)和辅助2 h(T3)四个时点监测CO,并同时采集动静脉血进行血气分析计算Pcv-aCO2值,分析Pcv-aCO2、中心静脉血氧饱和度(ScvO2)、乳酸(Lac)与CO相关性。结果 Pcv-aCO2与CO呈负相关(r=-0.457,P<0.05);ScvO2、Lac与CO之间无明显相关。结论犬ECMO辅助期间Pcv-aCO2与CO具有相关性,Pcv-aCO2可间接反映CO的变化趋势。Objective To investigate the relationship between Pcv-aCO2 and cardiac output （CO） of dogs during extracorporeal membrane oxygenation （ECMO）.Methods Five dogs treated with central venous catheterizations were placed via femoral vein,and artery piezometer tubes were placed in femoral artery to connect invasive cardiac output monitoring.Then ECMO mode was employed to monitor CO at four different time points：before ECMO establishment （To）,just after ECMO establishment （T1）,1 h after ECMO （T2） and 2 h after ECMO （T3）.At the same time,arterial and venous blood was collected to calculate the value of Pcv-aCO2 by blood-gas analysis and the separate correlations between CO and PcvaCO2,ScvO2,Lac were analyzed.Results Pcv-aCO2 showed a negative correlation with CO （r =-0.457 ; P ＜ 0.05） ;CO had no significant correlation with SaO2 and Lac.Conclusion CO of dogs has significant correlation with Pcv-aCO2 during ECMO,and Pcv-aCO2 can indirectly reflect the changing trend of CO.

关 键 词：体外膜肺氧合 动静脉二氧化碳分压差 心输出量 

分 类 号：R654[医药卫生—外科学]