大剂量甲氨蝶呤排泄延迟影响因素的研究进展  

Research Progress in Influence Factors of Excretion Delay of High-dose Methotrexate

作　　者：庞露[1] 刘立民[1] 肇丽梅[1] 

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《中国药学杂志》2013年第22期1892-1896,共5页Chinese Pharmaceutical Journal

基　　金：辽宁省科学技术计划项目(2009225020)

摘　　要：目的为使临床更加合理的使用甲氨蝶呤,减少不良反应发生,综述可能引起大剂量甲氨蝶呤排泄延迟的因素。方法通过查阅近期国内外相关文献,并进行归纳整理,总结可能引起大剂量甲氨蝶呤排泄延迟的相关因素。结果与结论患者生理状态、药物相互作用、药物代谢酶等多方面因素均可能导致甲氨蝶呤的排泄延迟,在临床应用中,应引起警惕,减少排泄延迟发生率,保证用药安全。OBJECTIVE In order to make a more rational clinical use of methotrexate and reduce adverse reactions, we summa- rize the factors that might cause excretion delay of high-dose methotrexate. METHODS After consulting relevant domestic and overseas documents published recently, we summed up some factors that might cause excretion delay of high-dose methotrexate. RESULTS AND CONCLUSION Physiological states of patients, drug interactions, drug-metabolizing enzymes, and many other factors all may lead to excretion delay of methotrexate. Therefore, we should pay attention to these factors to reduce the incidence of excretion delay and ensure safe medication in clinical application of methotrexate.

关 键 词：甲氨蝶呤 排泄延迟 影响因素 

分 类 号：R944[医药卫生—药剂学]