抗β2GPI抗体与β2GPI在血栓形成中作用的研究进展  

Research of anti-β2GPI/β2GPI induce cell changes in biological functions and promote thrombosis

作　　者：金美丽[1] 高飞[1] 刘彦虹[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医院检验科,150086

出　　处：《国际免疫学杂志》2013年第6期418-421,共4页International Journal of Immunology

基　　金：国家自然科学基金（81270394）

摘　　要：自身抗体在血栓性疾病的发病中的作用受到广泛关注。β2GPI又称载脂蛋白H（ApoH），主要由肝脏合成。抗β2GPI抗体（anti—β2GPI）是以β2GPI为靶抗原的抗磷脂抗体，研究表明体内高滴度的anti—β2GPI在体内血栓形成过程中具有极其关键的作用。Anti-β2GPI与β2GPI结合后与细胞表面的磷脂、脂蛋白等多种带负电荷的蛋白作用可引起细胞活化，通过多种途径促使血栓形成。深入研究anti-β2GPI／β2GPI在血栓性疾病发病机制可为自身抗体引起的血栓性疾病的治疗提供新的治疗靶点。Autoantibodies attracted widespread attention in the pathogenesis of thrombotic. β2GPI also known as Aport that synthesized by liver. Anti- β2 GPI antibo.dy（ anti -β2 GPI） is one of antiphospolipid anti-body which targets to human β2GPI. Binding of Anti -β2GPI and β2GPI leads to their interaction with phos- pholipids, lipoproteins and other negatively charged proteins on the cell surface, which then promote thrombosis a variety of ways. Further research on the mechanism of thrombotic induced by anti - β2 GPI/β2 GPI may pro-vide a new therapeutic target for thrombotic diseases caused by autoantibodies.

关 键 词：抗β2GPI抗体 Β2GPI 血栓形成 

分 类 号：R543[医药卫生—心血管疾病]