雌激素与绝经后妇女异丙酚靶控输注麻醉术后认知功能障碍关系的研究  

Relationship of Estrogen and Postoperative Cognitive Dysfunction in Postmenopausal Women with Propofol Targetcontrolled Infusion

作　　者：刘英伟[1] 赵香凤[1] 闵香[1] 郭海雁[1] 叶兹礼[1] 陈帅[1] 王凤君[1] 梁雄 

机构地区：[1]广东省珠海市妇幼保健院,519000 [2]珠海市第一人民医院

出　　处：《医学理论与实践》2013年第22期2943-2944,共2页The Journal of Medical Theory and Practice

基　　金：珠海市2010年度卫生局医学科研立项资助项目;项目基金号:2010036

摘　　要：目的:探讨雌激素与绝经后妇女异丙酚靶控输注麻醉术后认知功能障碍的关系。方法:将术前无认知障碍的40例妇科恶性肿瘤患者进行术后3d、7d认知功能评价,按MMSE得分将患者分为认知功能正常组和认知功能障碍组,所有患者术前均采用异丙酚靶控输注麻醉方式,测定及对比术前、术后3d及术后7d患者的空腹血清雌二醇浓度。结果:术后3d、7d正常组与障碍组术前血清雌二醇水平相比较无统计学意义,P>0.05;术后3d障碍组与正常组患者血清雌二醇分别为(51.9±12.6VS 84.7±19.2),7d血清雌二醇水平为(57.4±12.6VS 85.8±21.7),均P<0.05。结论:绝经后妇女异丙酚靶控输注麻醉术后认知功能障碍的发生可能与雌激素水平降低有关。Objective ：To explore the relationship of estrogen and postoperative cognitive dysfunction in postmenopaus-al women with propofol target-controlled infusion .Methods ：40 gynecologic malignancies patients with preoperative cog-nitive impairment were evaluated cognitive function at Postoperative 3d ,7d ,all patients were divided into normal cogni-tive function and cognitive dysfunction group according to MMSE scores ,and were used of propofol target-controlled infusion ,Measured and compared serum estradiol concentration at Postoperative 3d ,7d and Preoperative by fasting ve-nous blood .Results：Serum estradiol levels in the normal group and disorder group at Postoperative 3d ,7d were no sig-nificantly differences ,P〉0 .05 ,serum estradiol levels in the disorder group and normal group at Postoperative 3d were （51 .9 ± 12 .6 VS 84 .7 ± 19 .2） ,Postoperative 3d were（57 .4 ± 12 .6 VS 85 .8 ± 21 .7） ,it was no significantly differ-ences .Conclusion：Postmenopausal women with propofol target-controlled infusion may occur with the decreased levels of estrogen .

关 键 词：雌激素 绝经后妇女 异丙酚 靶控输注麻醉 术后认知功能障碍 

分 类 号：R614[医药卫生—麻醉学]