大理白族人脂联素基因多态性与原发性高血压的关系  

Genetic association analysis of variation in adiponectin gene with essential hypertension in Bai population in Dali

作　　者：康庄[1] 赵惠珠 苏恒[1] 张云[1] 虞艳芳[1] 欧杨[1] 薛元明[1] 

机构地区：[1]云南省第一人民医院内分泌科,昆明650032 [2]云南省大理州人民医院内分泌老年病科,671000

出　　处：《广东医学》2013年第19期2957-2959,共3页Guangdong Medical Journal

基　　金：云南省卫生科技计划项目(编号:2009NS015);中华医学会临床医学科研专项资金-内分泌疾病研究资金2010年度青年/地区资金资助项目(编号:10020130235)

摘　　要：目的研究云南省大理地区白族人群中脂联素基因(APM1)T45G及G276T多态性与原发性高血压(EH)的相关性。方法运用PCR-直接测序技术在白族对照人群及EH患者中进行APM1 T45G及G276T多态性检测。结果 APM1 45位点G等位基因频率在EH组和对照组间差异有统计学意义(36.6%vs 24.6%,P<0.05);+45T>G和+276G>T位点连锁,单倍型+276G+45G的频率在EH组高于对照组(P<0.05)。结论白族人群中,APM1 SNP+45G等位基因可能与EH的发生相关,+45G+276G是EH的危险单倍型。Objective To study the possible association of adiponectin gene（APM1 ） T45G and G276T polymorphisms with essential hypertension（EH） in Bai population in Dali area. Methods APM1 snps 45T 〉 G（rs2241766） and 276G 〉 T（rs1501299） were detected by DNA sequencing in EH patients （n = 153） and healthy controls （n = 126）. Resuits The allele g frequency of ＋ 45 polymorphism was significantly higher in EH group （36. 6% ） than that in control group（24. 6% ）. Linkage disequilibrium （LD） analysis showed significant LD between 45T 〉 G and 276G 〉 T. The haplotype ＋ 45G ＋ 276G frequency in EH group was significantly higher than control group（P 〈 0. 05 ）. Conclusion In Bai population,the APM1 ＋ 45G allele may contribute to the development of essential hypertension, and ＋ 45G ＋ 276G may be a risk haplotype.

关 键 词：脂联素基因 单核苷酸多态性 原发性高血压 大理白族 

分 类 号：R544.1[医药卫生—心血管疾病]