UCP-2基因-866G>A突变与2型糖尿病脑卒中复发的相关性  

Correlation of uncoupling protein 2 gene-866G/A mutation and stroke recurrence in patients with type 2 diabetes mellitus

作　　者：顾兵 朱倩 张璐 柴怡 

机构地区：[1]南京医科大学第一附属医院检验学部,江苏省210029 [2]南京医科大学第一附属医院临床药理基地,江苏省210029

出　　处：《江苏医药》2013年第21期2531-2534,共4页Jiangsu Medical Journal

基　　金：科技部科技重大专项"重大新药创制"(2011ZX09302-003-02);江苏省科技重大专项(BM2011017);江苏高校优势学科建设工程资助项目

摘　　要：目的探讨解耦联蛋白(UCP)-2基因-866G>A突变与2型糖尿病(T2DM)脑卒中复发相关性。方法 4年随访观察405例脑卒中初发的T2DM患者相关临床危险因素,比较发生终点事件(A组,183例)和未发生终点事件(B组,222例)的基因型分布。二磷酸腺苷(ADP)和(或)肾上腺素作为诱导剂测定血小板聚集率。分析基因分型与抗血小板药物的相关性。结果两组各基因型分布并无统计学差异(P>0.05)。与GG野生型患者相比,携带A等位基因的高龄肥胖男性患者增加脑卒中复发风险(P<0.05)。携带A等位基因的患者发生氯吡格雷抵抗的几率远远高于GG野生型患者(P<0.01)。结论 UCP-2基因-866G>A突变可能引发氯吡格雷抵抗,从而对T2DM脑卒中复发及预后产生影响。Objective To study the correlation between uncoupling protein 2 （UCP-2） gene -866G/A mutation and stroke recurrence in patients with type 2 diabetes mellitus（T2DM）. Methods The risk factors for stroke recurrence were observed in 405 T2DM patients with stroke in four-year follow up. Genotype distribution in groups of A（with end events, 183 cases） and B（without end events,222 cases） was compared. Platelet aggregation rate was detected by inducer （adenosine diphosphate or epinephrine）. Correlation between genotype and antiplatelet drug was analyzed. Results There was no significant difference in genotype distribution between two groups（P〈0. 05）. Compared with patients with GCrwild type, recurrent risk for stroke increased in eider, obese male patients with A allele（P〈0. 05）. Incidence rate of clopidogrel resistance was higher in patients with A allele than that in patients with GG-wild type（P〈0. 01）. Conclusion UCP-2 gene -866G/A mutation may cause clopidogrel resistance and has effect on stroke recurrence and prognosis in patients with T2DM.

关 键 词：解偶联蛋白2 -866G〉A 2型糖尿病 脑卒中 

分 类 号：R587[医药卫生—内分泌]