胰岛自身抗体检测在2型糖尿病视网膜病变中的意义  

Significance of detection of islet autoantibodies in evaluating diabetic retinopathy of patients with type 2 diabetes mellitus

作　　者：王蕾[1] 刘步云[1] 

机构地区：[1]南通市第一人民医院急诊内科,江苏省226000

出　　处：《江苏医药》2013年第21期2562-2564,共3页Jiangsu Medical Journal

摘　　要：目的探讨胰岛自身抗体检测在2型糖尿病(T2DM)视网膜病变发生发展中的意义。方法根据眼底荧光造影检查,将211例T2DM患者分为背景期视网膜病变(A组)、增殖期视网膜病变(B组)和无视网膜病变(C组)三组。检测血清胰岛细胞抗体(ICA)、谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗原2抗体(IA-2A)、胰岛素抗体(IAA)的阳性率及糖化血红蛋白(HbA1c)水平。结果 A、B组GADA阳性率高于C组(P<0.01),且B组GADA阳性率高于A组(P<0.05);C组ICA阳性率高于B组(P<0.01);A、B组HbA1c水平高于C组(P<0.01),且B组的HbA1c水平高于A组(P<0.01)。结论胰岛自身抗体检测及血糖控制状况有助于评估T2DM视网膜病变程度。Objective To investigate the significance of islet autoantibodies in evaluating the occurrence and development of diabetic retinopathy in the patients with type 2 diabetes mellitus （T2DM）. Methods On the basis of cheracteristics seen on the fundus fluorescent imaging, 211 T2DM patients were divided into three groups of A, B and C. Serum islet cell antibody（ICA）, glutamic acid decarboxylase antibody（GADA）, islet antigen-2 antibody （IA-2A） and islet autoantibody （IAA） and glycosylated hemoglobinAlc （HbAlc） were detected and compared among three groups. Results Positive rate of GADA in groups of A and B were higher than that in group C（P〈0. 01）, which was higher in group B than that in group A（P〈0. 05）. Positive rate of ICA in group C was higher than that in group B（P〈0. 01）. The HbAlc was higher in groups of A and B than that in goup C, which was higher in group B than that in group A（P〈0. 01）. Conclusion Detection of islet autoantibodies and glycemic control are helpful for evaluating and predicting the severity of diabetic retinopathy in T2DM patients.

关 键 词：2型糖尿病 糖尿病视网膜病变 胰岛自身抗体 

分 类 号：R587[医药卫生—内分泌]