B淋巴细胞刺激因子与糖尿病患者颈动脉粥样斑块的相关性  

Relationship between serum B-lymphocyte stimulator and carotid plague in patients with type 2 diabetes mellitus

作　　者：陈旖婷[1] 成兴波[1] 

机构地区：[1]苏州大学附属第一医院内分泌病科,江苏省215006

出　　处：《江苏医药》2013年第21期2573-2575,共3页Jiangsu Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)患者血清B淋巴细胞刺激因子(BLyS)与颈动脉粥样斑块的相关性。方法采用双抗夹心酶联免疫吸附试验检测T2DM无颈动脉斑块患者(A组,40例)、T2DM合并颈动脉斑块患者(B组,38例)及正常对照者(C组,38例)血清BLyS和肿瘤坏死因子(TNF-α)表达。结果 B组和A组血清BLyS水平均高于C组[(1022.95±254.4)μg/L和(759.72±243.15)μg/L vs.(583.48±171.7)μg/L](P<0.05),B组血清BLyS水平高于A组(P<0.05)。A组、B组血清BLyS水平与TNF-α呈正相关(P<0.05)。结论 T2DM合并颈动脉粥样斑块患者BLyS与TNF-α高表达,提示BLyS可能参与颈动脉粥样斑块的形成。Objective To explore the relationship between B-lymphocyte stimulator（BLyS） and carotid plague in patients with type 2 diabetes mellitus（T2DM）. Methods Serum BLyS levels were measured by ELISA in 78 T2DM patients and 38 healthy controls（group C）. T2DM patients were divided into group A（40 cases without carotid plague） and group B（38 cases with carotid plague）. Tumor necrosis factor（TNF）-α and some other metabolic variables were determined as well. Results Serum BLyS level was significantly higher in groups of B and A than that in group C [（1022.95±254. 4） μg/L and （759. 72±243.15） μg/L vs. （583. 48±171.7）μg/L] （P〈0. 05）,which was higher in group B than that in group A（P〈0. 05）. Serum BLyS level was positively correlated with TNF-α in groups of A and B（P〈0. 05）. Conclusion The BLyS and TNF-α are highly expressed in T2DM patients with carotid plague, suggesting that serum BLyS may play a role in developing carotid plague.

关 键 词：2型糖尿病 B淋巴细胞刺激因子 颈动脉粥样斑块 

分 类 号：R587[医药卫生—内分泌]