梅毒螺旋体膜蛋白研究进展  

Advances in treponema pallidum membrane protein.

作　　者：刘琼[1] 刘双全[1] 张秋桂[1] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001

出　　处：《微生物学免疫学进展》2013年第5期56-59,共4页Progress In Microbiology and Immunology

基　　金：国家自然科学基金资助项目(81201331);湖南省自然科学基金资助项目(11JJ4076);2011年湖南省教育厅青年基金资助项目(11B107)

摘　　要：梅毒螺旋体苍白亚种(Tp)引起的梅毒是一种严重危害人类健康的慢性性传播性疾病,其发病具有多阶段、进行性的特点。由于Tp尚不能体外培养,抗原获取困难,其致病机制研究尚不清楚。随着Tp全基因序列的解析,重组Tp膜蛋白的成功表达及蛋白功能结构日益明确,为Tp发病机制的研究及疫苗的研制奠定了良好的基础。对于Tp主要外膜蛋白的结构、功能研究进展进行了综述。Syphilis is a serious sexually transmitted disease , caused by treponema pallidum subsp.Pallidum （ T.palli-dum） , with the disease characteristics of multistage and progressive .As T.pallidum cannot be cultured in vitro , it is really hard to acquire its antigen and thus its pathogenic mechanism is still unclear .With the publication of T.pallidum gene se-quence , the successful expression of membrane protein and more understanding of the function and structure of T.pallidum protein, it has laid a good foundation for the research of T.pallidum pathogenesis , as well as the development of vaccine . This review attempts to give an overview about the structure and function of T.pallidum membrane protein .

关 键 词：梅毒螺旋体 膜蛋白 致病机制 疫苗 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]